Phenotypes associated with this allele
Allelic
Composition |
Mecp2tm1Pplt/Mecp2+
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Pplt mutation
(0 available);
any
Mecp2 mutation
(38 available)
|
|
|
behavior/neurological
 |
• motor defect on initial exposure to rotarod test
• rotarod performance normalized when maintained in an "enriched" environment
• rotarod performance improves over 5 days of training
• rotarod performance remains deficient relative to wild-type kept in a standard environment
• coordination improvement acquired with training is lost in the weeks subsequent to training
• "enriched" environment prevents coordination deficiency from developing
|
|
|
• reduced rearing activity regardless of the environment
|
Allelic
Composition |
Mecp2tm1Pplt/Y
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Pplt mutation
(0 available);
any
Mecp2 mutation
(38 available)
|
|
|
Allelic
Composition |
Mecp2tm1Pplt/Y
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C3H/HeSn |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Pplt mutation
(0 available);
any
Mecp2 mutation
(38 available)
|
|
|
mortality/aging
 |
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• 50% dead by 7 weeks
|
growth/size/body
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• reported for this background
|
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• progressive weight loss after 11 weeks of age
|
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• growth normal until 5 weeks of age
• growth retardation after 5 weeks
|
behavior/neurological
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• accompanies weight loss
|
craniofacial
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• reported for this background
|
skeleton
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• reported for this background
|
Allelic
Composition |
Mecp2tm1Pplt/Y
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Pplt mutation
(0 available);
any
Mecp2 mutation
(38 available)
|
|
|
mortality/aging
|
|
• 50% lethality by 8 weeks
|
growth/size/body
|
|
• marked weight loss starting about 1 week before death
|
|
|
• failure to thrive after 5 weeks
• mean weight 15 g at 8 weeks comppared to 21 g for controls
|
behavior/neurological
|
N |
• general locomotion is normal through 6 weeks of age
|
|
|
• reduced ability to associate foot shock with context
|
|
|
• reduced ability to associate auditory cue to footshock
|
|
|
• as measured on an elevated + maze
|
|
|
• clasping of hind limbs when lifted by the tail
|
|
|
• coordination remains impaired through week 9
(J:137344)
• time spent on an accelerating rotarod about 1/3 that of controls
(J:137513)
• no improvement with successive trials
(J:137513)
|
|
|
• less rearing behavior when maintained in a standard environment
|
|
|
• lower activity levels on free wheels in mice before onset of breathing problems or seizures
|
nervous system
respiratory system
integument
Allelic
Composition |
Mecp2tm1Pplt/0
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C3H/HeSn |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Pplt mutation
(0 available);
any
Mecp2 mutation
(38 available)
|
|
|
mortality/aging
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• 50% dead by 7 weeks
|
growth/size/body
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• reported for this background
|
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• progressive weight loss after 11 weeks of age
|
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• growth normal for first 6-7 weeks of life
• growth retardation after 7 weeks
|
behavior/neurological
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• accompanies weight loss
|
craniofacial
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• reported for this background
|
skeleton
|
|
• these mice retain the neo insert in the Mecp2tm1Pplt allele
• reported for this background
|
Analysis Tools