Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(935 available)
Mcl1tm1Ywh mutation
(0 available);
any
Mcl1 mutation
(33 available)
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immune system
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• in culture following treatment with tamoxifen regardless of activation status T cell survival is decreased comapred to similarly treated wild-type cells
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cellular
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• in culture following treatment with tamoxifen regardless of activation status T cell survival is decreased comapred to similarly treated wild-type cells
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hematopoietic system
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• in culture following treatment with tamoxifen regardless of activation status T cell survival is decreased comapred to similarly treated wild-type cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
Mcl1tm1Ywh mutation
(0 available);
any
Mcl1 mutation
(33 available)
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immune system
N |
• despite reduced neutrophil numbers and recruitment, the number of monocytes, recruitment of macrophages during peritonitis and macrophage survival and cytokine production after Toll-like receptor stimulation are normal
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• in the blood, spleen and bone marrow
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• the number of Mac-1+Gr1+ granulocytes is decreased in the bone marrow as well as decreased 80% in peripheral blood and 86% in spleen compared to in wild-type mice
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• the number of neutrophils is reduced by 80% compared to in wild-type mice due to increased apoptosis of neutrophils
• however, mice that do not exhibit proper cre-mediated deletion survive
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• apoptosis of neutrophils is enhanced
• however, mice that do not exhibit proper cre-mediated deletion survive
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• mice exhibit an 80% decrease in neutrophils recruited to peritoneal cells treated with thioglycollate to induce peritonitis compared to similarly treated wild-type mice
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hematopoietic system
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• in the blood, spleen and bone marrow
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• the number of Mac-1+Gr1+ granulocytes is decreased in the bone marrow as well as decreased 80% in peripheral blood and 86% in spleen compared to in wild-type mice
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• the number of neutrophils is reduced by 80% compared to in wild-type mice due to increased apoptosis of neutrophils
• however, mice that do not exhibit proper cre-mediated deletion survive
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• apoptosis of neutrophils is enhanced
• however, mice that do not exhibit proper cre-mediated deletion survive
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• mice exhibit an 80% decrease in neutrophils recruited to peritoneal cells treated with thioglycollate to induce peritonitis compared to similarly treated wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Ywh mutation
(0 available);
any
Mcl1 mutation
(33 available)
Tg(Lck-cre)548Jxm mutation
(2 available)
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immune system
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• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
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• thymus contain 5% of the cells found in wild-type mice
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• T cell development is blocked between DN2/3 and DN4 stages
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
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• T cell numbers in the spleen are 40% to 50% of wild-type
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hematopoietic system
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• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
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• thymus contain 5% of the cells found in wild-type mice
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• T cell development is blocked between DN2/3 and DN4 stages
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
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• T cell numbers in the spleen are 40% to 50% of wild-type
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cellular
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• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
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endocrine/exocrine glands
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• thymus contain 5% of the cells found in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Ywh mutation
(0 available);
any
Mcl1 mutation
(33 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• the number of mature T cells in the spleen is less than 10% of wild-type
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• slight increase in the frequency
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• the number of mature T cells in the spleen is less than 10% of wild-type
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• the frequency of total CD4+ thymocytes and mature CD4+ thymocytes is decreased compared to in wild-type mice
• few CD4+ T cells are detected
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• the frequency of CD8+ T cells is reduced by greater than 80% compared to in wild-type mice
• the frequency of mature CD8+ thymocytes is reduced over 10-fold compared to in wild-type mice
• few CD8+ T cells are detected
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hematopoietic system
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• the number of mature T cells in the spleen is less than 10% of wild-type
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• slight increase in the frequency
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• the number of mature T cells in the spleen is less than 10% of wild-type
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• the frequency of total CD4+ thymocytes and mature CD4+ thymocytes is decreased compared to in wild-type mice
• few CD4+ T cells are detected
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• the frequency of CD8+ T cells is reduced by greater than 80% compared to in wild-type mice
• the frequency of mature CD8+ thymocytes is reduced over 10-fold compared to in wild-type mice
• few CD8+ T cells are detected
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cellular
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• the number of mature T cells in the spleen is less than 10% of wild-type
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1Ywh mutation
(0 available);
any
Bcl2l1 mutation
(104 available)
Mcl1tm1Ywh mutation
(0 available);
any
Mcl1 mutation
(33 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• the frequency of double positive T cells is reduced to 45% of thymocytes compared to 85% in wild-type mice
• the absolute number of double positive cells is 10% of wild-type
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hematopoietic system
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• the frequency of double positive T cells is reduced to 45% of thymocytes compared to 85% in wild-type mice
• the absolute number of double positive cells is 10% of wild-type
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