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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mcl1tm1Ywh
targeted mutation 1, You-Wen He
MGI:3800294
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Mcl1tm1Ywh/Mcl1tm1Ywh
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 MGI:3801467
cn2
Mcl1tm1Ywh/Mcl1tm1Ywh
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:3801426
cn3
Mcl1tm1Ywh/Mcl1tm1Ywh
Tg(Lck-cre)548Jxm/0
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA MGI:3801464
cn4
Mcl1tm1Ywh/Mcl1tm1Ywh
Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3801466
cn5
Bcl2l1tm1Ywh/Bcl2l1tm1Ywh
Mcl1tm1Ywh/Mcl1tm1Ywh
Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3801468


Genotype
MGI:3801467
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Mcl1tm1Ywh/Mcl1tm1Ywh
Genetic
Background
involves: 129/Sv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (935 available)
Mcl1tm1Ywh mutation (0 available); any Mcl1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in culture following treatment with tamoxifen regardless of activation status T cell survival is decreased comapred to similarly treated wild-type cells

cellular
• in culture following treatment with tamoxifen regardless of activation status T cell survival is decreased comapred to similarly treated wild-type cells

hematopoietic system
• in culture following treatment with tamoxifen regardless of activation status T cell survival is decreased comapred to similarly treated wild-type cells




Genotype
MGI:3801426
cn2
Allelic
Composition
Mcl1tm1Ywh/Mcl1tm1Ywh
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Mcl1tm1Ywh mutation (0 available); any Mcl1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• despite reduced neutrophil numbers and recruitment, the number of monocytes, recruitment of macrophages during peritonitis and macrophage survival and cytokine production after Toll-like receptor stimulation are normal
• in the blood, spleen and bone marrow
• the number of Mac-1+Gr1+ granulocytes is decreased in the bone marrow as well as decreased 80% in peripheral blood and 86% in spleen compared to in wild-type mice
• the number of neutrophils is reduced by 80% compared to in wild-type mice due to increased apoptosis of neutrophils
• however, mice that do not exhibit proper cre-mediated deletion survive
• apoptosis of neutrophils is enhanced
• however, mice that do not exhibit proper cre-mediated deletion survive
• mice exhibit an 80% decrease in neutrophils recruited to peritoneal cells treated with thioglycollate to induce peritonitis compared to similarly treated wild-type mice

hematopoietic system
• in the blood, spleen and bone marrow
• the number of Mac-1+Gr1+ granulocytes is decreased in the bone marrow as well as decreased 80% in peripheral blood and 86% in spleen compared to in wild-type mice
• the number of neutrophils is reduced by 80% compared to in wild-type mice due to increased apoptosis of neutrophils
• however, mice that do not exhibit proper cre-mediated deletion survive
• apoptosis of neutrophils is enhanced
• however, mice that do not exhibit proper cre-mediated deletion survive
• mice exhibit an 80% decrease in neutrophils recruited to peritoneal cells treated with thioglycollate to induce peritonitis compared to similarly treated wild-type mice




Genotype
MGI:3801464
cn3
Allelic
Composition
Mcl1tm1Ywh/Mcl1tm1Ywh
Tg(Lck-cre)548Jxm/0
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Ywh mutation (0 available); any Mcl1 mutation (33 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
• thymus contain 5% of the cells found in wild-type mice
• T cell development is blocked between DN2/3 and DN4 stages
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
• 5% to 10% of wild-type
• T cell numbers in the spleen are 40% to 50% of wild-type

hematopoietic system
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
• thymus contain 5% of the cells found in wild-type mice
• T cell development is blocked between DN2/3 and DN4 stages
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
• T cell numbers in the spleen are 40% to 50% of wild-type
• 5% to 10% of wild-type

cellular
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice

endocrine/exocrine glands
• thymus contain 5% of the cells found in wild-type mice




Genotype
MGI:3801466
cn4
Allelic
Composition
Mcl1tm1Ywh/Mcl1tm1Ywh
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Ywh mutation (0 available); any Mcl1 mutation (33 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the number of mature T cells in the spleen is less than 10% of wild-type
• slight increase in the frequency
• the number of mature T cells in the spleen is less than 10% of wild-type
• the frequency of total CD4+ thymocytes and mature CD4+ thymocytes is decreased compared to in wild-type mice
• few CD4+ T cells are detected
• the frequency of CD8+ T cells is reduced by greater than 80% compared to in wild-type mice
• the frequency of mature CD8+ thymocytes is reduced over 10-fold compared to in wild-type mice
• few CD8+ T cells are detected

hematopoietic system
• the number of mature T cells in the spleen is less than 10% of wild-type
• slight increase in the frequency
• the number of mature T cells in the spleen is less than 10% of wild-type
• the frequency of total CD4+ thymocytes and mature CD4+ thymocytes is decreased compared to in wild-type mice
• few CD4+ T cells are detected
• the frequency of CD8+ T cells is reduced by greater than 80% compared to in wild-type mice
• the frequency of mature CD8+ thymocytes is reduced over 10-fold compared to in wild-type mice
• few CD8+ T cells are detected

cellular
• the number of mature T cells in the spleen is less than 10% of wild-type




Genotype
MGI:3801468
cn5
Allelic
Composition
Bcl2l1tm1Ywh/Bcl2l1tm1Ywh
Mcl1tm1Ywh/Mcl1tm1Ywh
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1Ywh mutation (0 available); any Bcl2l1 mutation (104 available)
Mcl1tm1Ywh mutation (0 available); any Mcl1 mutation (33 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the frequency of double positive T cells is reduced to 45% of thymocytes compared to 85% in wild-type mice
• the absolute number of double positive cells is 10% of wild-type

hematopoietic system
• the frequency of double positive T cells is reduced to 45% of thymocytes compared to 85% in wild-type mice
• the absolute number of double positive cells is 10% of wild-type





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory