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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CYP19A1-cre)1Jri
transgene insertion 1, JoAnne Richards
MGI:3799733
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
involves: 129S4/SvJae MGI:4847591
cn2
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
involves: 129S4/SvJae * 129S6/SvEvTac MGI:5784501
cn3
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(CYP19A1-cre)1Jri/0
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5432224
cn4
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5432226
cn5
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Tg(CYP19A1-cre)1Jri/0
involves: 129S6/SvEvTac MGI:5784494
cn6
Ctnnb1tm1Mmt/Ctnnb1+
Tg(CYP19A1-cre)1Jri/0
involves: 129X1/SvJ * C57BL/6 MGI:5432223


Genotype
MGI:4847591
cn1
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (3 available); any Pten mutation (39 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• the increased numbers of corpora lutea are at different stages of differentiation than in controls
• luteolysis is dramatically impaired and delayed in mutants on a superovulatory regimen of eCG/hCG compared to wild-type mice
• steroid biosynthesis is similar in mutants as in controls indicating that even though life span of corpora lutea are extended, they do not remain steroidogenically active
• after 3 months of age, ovaries contain increased numbers of corpora lutea
• females exhibit increased follicle growth
• numbers of apoptotic follicles decreased in eCG-primed mutant ovaries
• granulosa cells exhibit increased proliferation
• numbers of cleaved caspase 3 (CC3)-positive granulosa cells are decreased in eCG-primed mutant ovaries
• after 3 months of age, ovaries are larger and contain increased numbers of corpora lutea

reproductive system
• the increased numbers of corpora lutea are at different stages of differentiation than in controls
• luteolysis is dramatically impaired and delayed in mutants on a superovulatory regimen of eCG/hCG compared to wild-type mice
• steroid biosynthesis is similar in mutants as in controls indicating that even though life span of corpora lutea are extended, they do not remain steroidogenically active
• after 3 months of age, ovaries contain increased numbers of corpora lutea
• females exhibit increased follicle growth
• numbers of apoptotic follicles decreased in eCG-primed mutant ovaries
• granulosa cells exhibit increased proliferation
• numbers of cleaved caspase 3 (CC3)-positive granulosa cells are decreased in eCG-primed mutant ovaries
• after 3 months of age, ovaries are larger and contain increased numbers of corpora lutea
• immature females primed with a superovulatory regiment of equine chorionic gonadotropin (eCG), followed by human CG, ovulate more oocytes than control mice, indicating advanced ovulation rate and increased ovulation
• females give birth to approximately 20% more pups than controls during a 6-month breeding period

neoplasm
N
• females do not develop ovarian tumors

cellular
• granulosa cells exhibit increased proliferation
• numbers of cleaved caspase 3 (CC3)-positive granulosa cells are decreased in eCG-primed mutant ovaries
• the increased numbers of corpora lutea are at different stages of differentiation than in controls
• luteolysis is dramatically impaired and delayed in mutants on a superovulatory regimen of eCG/hCG compared to wild-type mice
• steroid biosynthesis is similar in mutants as in controls indicating that even though life span of corpora lutea are extended, they do not remain steroidogenically active




Genotype
MGI:5784501
cn2
Allelic
Composition
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (7 available)
Foxo1tm1Rdp mutation (1 available); any Foxo1 mutation (7 available)
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (11 available)
Foxo3tm1Rdp mutation (1 available); any Foxo3 mutation (11 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (39 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early

homeostasis/metabolism
• tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B
• serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice
• serum luteinizing hormone levels are below the level of detection in tumor bearing mice

neoplasm
• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early

reproductive system
• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early




Genotype
MGI:5432224
cn3
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Tg(CYP19A1-cre)1Jri/0
Genetic
Background
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (22 available)
Krastm4Tyj mutation (6 available); any Kras mutation (35 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die within 3.5-5.5 months of age

neoplasm
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
• female mutants develop bilateral granulosa cell tumors by 3 months of age

endocrine/exocrine glands
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
• female mutants develop bilateral granulosa cell tumors by 3 months of age

reproductive system
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
• female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age
• female mutants develop bilateral granulosa cell tumors by 3 months of age

homeostasis/metabolism
• at 6 weeks of age in females
• at 6 weeks of age in females
• at 6 weeks of age in females

cellular
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
granulosa cell tumor DOID:2999 J:186144
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
J:186144




Genotype
MGI:5432226
cn4
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
Genetic
Background
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (22 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (39 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mutants die within 2-3 months of age due to tumor burden

neoplasm
• mutants exhibit precancerous lesions in the ovaries by 3 weeks of age
• mutants develop large granulosa cell tumors by 6-8 weeks of age

endocrine/exocrine glands
• granulosa cell proliferation is increased and apoptosis is decreased in the ovaries at 5-6 weeks of age
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
• mutants exhibit precancerous lesions in the ovaries by 3 weeks of age
• mutants develop large granulosa cell tumors by 6-8 weeks of age

reproductive system
• granulosa cell proliferation is increased and apoptosis is decreased in the ovaries at 5-6 weeks of age
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
• mutants exhibit precancerous lesions in the ovaries by 3 weeks of age
• mutants develop large granulosa cell tumors by 6-8 weeks of age

homeostasis/metabolism

cellular
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
granulosa cell tumor DOID:2999 J:186144
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
J:186144




Genotype
MGI:5784494
cn5
Allelic
Composition
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Tg(CYP19A1-cre)1Jri/0
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1.1Rdp mutation (0 available); any Foxo1 mutation (7 available)
Foxo1tm1Rdp mutation (1 available); any Foxo1 mutation (7 available)
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (11 available)
Foxo3tm1Rdp mutation (1 available); any Foxo3 mutation (11 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin exhibit ovaries with many abnormal, degenerating follicles in which oocytes are shrunken or absent
• in some follicles of mice injected with superovulatory levels of equine gonadotropin and human gonadotropin, granulosa cells are abnormally displaced and growing on one side
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

homeostasis/metabolism
• tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B
• serum levels of estradiol are elevated in tumor bearing mice
• serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice
• serum luteinizing hormone levels are below the level of detection in tumor bearing mice

neoplasm
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

reproductive system
• 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin exhibit ovaries with many abnormal, degenerating follicles in which oocytes are shrunken or absent
• in some follicles of mice injected with superovulatory levels of equine gonadotropin and human gonadotropin, granulosa cells are abnormally displaced and growing on one side
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
J:232961




Genotype
MGI:5432223
cn6
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Tg(CYP19A1-cre)1Jri/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (22 available)
Tg(CYP19A1-cre)1Jri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• ovaries exhibit visible precancerous lesions between 4 and 6 weeks of age and develop granulosa cell tumors

reproductive system
• ovaries exhibit visible precancerous lesions between 4 and 6 weeks of age and develop granulosa cell tumors

mortality/aging
• mutants die within 6-8 months of age

neoplasm
• ovaries exhibit visible precancerous lesions between 4 and 6 weeks of age and develop granulosa cell tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
J:186144





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory