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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APOE-NPC1L1)20Lqyu
transgene insertion 20, Liqing Yu
MGI:3799059
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(APOE-NPC1L1)20Lqyu/0 involves: C57BL/6 * DBA/2 MGI:3799060


Genotype
MGI:3799060
tg1
Allelic
Composition
Tg(APOE-NPC1L1)20Lqyu/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APOE-NPC1L1)20Lqyu mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• when fed a 0.2% cholesterol diet, modestly but significantly, higher amounts of hepatic free cholesterol and phospholipids are found, compared to wild-type
• no difference in cholesteryl ester or triglyceride concentrations are observed on this diet
• when fed a 0.015% cholesterol diet, plasma total cholesterol is increased by 43% and plasma free cholesterol is elevated 41% relative to wild-type; on a 0.2% cholesterol diet, plasma total cholesterol and free cholesterol are significantly higher than in wild-type mice

liver/biliary system
• on a 0.015% cholesterol diet, gallbladder cholesterol is increased 13-fold compared to wild-type, whereas phospholipid and bile acid concentrations are maintained
• on a 0.2% cholesterol diet, cholesterol increases in the gallbladder, but levels are 5-fold lower than wild-type
• molar ratios of biliary cholesterol are 14-fold lower when fed a 0.015% cholesterol diet, and 5-fold lower on a 0.2% cholesterol diet compared to wild-type mice
• biliary cholesterol excretion is restored by treatment with ezetimide for 4 days; bile from treated mice has a 10-fold higher cholesterol concentration compared to vehicle-treated transgenic mice, but molar ratio of biliary cholesterol in treated mutants is similar to levels in treated wild-type





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory