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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mta2tm1.1Yzha
targeted mutation 1.1, Yi Zhang
MGI:3798815
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mta2tm1.1Yzha/Mta2tm1.1Yzha involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3803013


Genotype
MGI:3803013
hm1
Allelic
Composition
Mta2tm1.1Yzha/Mta2tm1.1Yzha
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mta2tm1.1Yzha mutation (0 available); any Mta2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Adult Mta2tm1.1Yzha/Mta2tm1.1Yzha mice exhibit autoimmunity-related phenotypes in multiple organs

mortality/aging
• fewer than 50% of mice survive into adulthood (J:137101)
• fewer than 50% of mice survive into adulthood (J:137101)
• about half of mice exhibit embryonic or perinatal lethality (J:137101)
• about half of mice exhibit embryonic or perinatal lethality (J:137101)
• mice exhibit a shorter than normal life span that is shorter in female mice than in male mice (J:137101)
• mice exhibit a shorter than normal life span that is shorter in female mice than in male mice (J:137101)
• about half of mice exhibit embryonic or perinatal lethality (J:137101)
• Background Sensitivity: embryonic lethality is more severe on a C57BL/6 background (J:137101)
• about half of mice exhibit embryonic or perinatal lethality (J:137101)
• Background Sensitivity: embryonic lethality is more severe on a C57BL/6 background (J:137101)

immune system
• hyperproliferation follows stimulation with antiCD3 or anti-CD3 and anti-CD8 antibodies (J:137101)
• CD4+CD25- peripheral T cells exhibit hyperproliferation (J:137101)
• hyperproliferation follows stimulation with antiCD3 or anti-CD3 and anti-CD8 antibodies (J:137101)
• CD4+CD25- peripheral T cells exhibit hyperproliferation (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• mice exhibit increased susceptibility to systemic lupus erythematosus that can be transferred by bone marrow transplant (J:137101)
• mice exhibit increased susceptibility to systemic lupus erythematosus that can be transferred by bone marrow transplant (J:137101)
• mice exhibit an increase in anti-dsDNA, anti-SM. anti-SSA(Ro) and anti-SSB(La) autoantibodies compared to in wild-type mice (J:137101)
• mice exhibit an increase in anti-dsDNA, anti-SM. anti-SSA(Ro) and anti-SSB(La) autoantibodies compared to in wild-type mice (J:137101)
• in more than half of mice and generally limited to the portal regions (J:137101)
• in more than half of mice and generally limited to the portal regions (J:137101)
• mice exhibit dermal and subcutaneous inflammation (panniculitis) (J:137101)
• mice exhibit dermal and subcutaneous inflammation (panniculitis) (J:137101)
• some mice exhibit lymphocyte-rich chronic inflammatory cell infiltration (J:137101)
• some mice exhibit lymphocyte-rich chronic inflammatory cell infiltration (J:137101)
• chronic (J:137101)
• chronic (J:137101)
• chronic spongiotic dermatitis (J:137101)
• chronic spongiotic dermatitis (J:137101)

homeostasis/metabolism
N
• despite an increase in alanine transaminase levels, the level of aspartate aminotransferase and alkaline phosphatase levels are normal (J:137101)
• despite an increase in alanine transaminase levels, the level of aspartate aminotransferase and alkaline phosphatase levels are normal (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions (J:137101)
• 40% of mice exhibit moderate or high urine protein levels with female mice exhibiting a more severe phenotype than male mice (J:137101)
• 40% of mice exhibit moderate or high urine protein levels with female mice exhibiting a more severe phenotype than male mice (J:137101)

renal/urinary system
• mice exhibit global mesangial cell proliferation in the kidney (J:137101)
• mice exhibit global mesangial cell proliferation in the kidney (J:137101)
• 40% of mice exhibit moderate or high urine protein levels with female mice exhibiting a more severe phenotype than male mice (J:137101)
• 40% of mice exhibit moderate or high urine protein levels with female mice exhibiting a more severe phenotype than male mice (J:137101)
• some mice exhibit lymphocyte-rich chronic inflammatory cell infiltration (J:137101)
• some mice exhibit lymphocyte-rich chronic inflammatory cell infiltration (J:137101)
• mice exhibit global mesangial cell proliferation in the kidney (J:137101)
• mice exhibit global mesangial cell proliferation in the kidney (J:137101)

reproductive system
(J:137101)
(J:137101)

liver/biliary system
• in more than half of mice and generally limited to the portal regions (J:137101)
• in more than half of mice and generally limited to the portal regions (J:137101)

skeleton

craniofacial

growth/size/body
• body size is two-thirds of normal prior to weaning and after reaching maturity (J:137101)
• body size is two-thirds of normal prior to weaning and after reaching maturity (J:137101)

hematopoietic system
• hyperproliferation follows stimulation with antiCD3 or anti-CD3 and anti-CD8 antibodies (J:137101)
• CD4+CD25- peripheral T cells exhibit hyperproliferation (J:137101)
• hyperproliferation follows stimulation with antiCD3 or anti-CD3 and anti-CD8 antibodies (J:137101)
• CD4+CD25- peripheral T cells exhibit hyperproliferation (J:137101)

integument
• mice exhibit dermal and subcutaneous inflammation (panniculitis) (J:137101)
• mice exhibit dermal and subcutaneous inflammation (panniculitis) (J:137101)
• chronic (J:137101)
• chronic (J:137101)
• chronic spongiotic dermatitis (J:137101)
• chronic spongiotic dermatitis (J:137101)
• in some areas mice exhibit immature and decreased hair follicles (J:137101)
• however, frank alopecia is not observed (J:137101)
• in some areas mice exhibit immature and decreased hair follicles (J:137101)
• however, frank alopecia is not observed (J:137101)
• mice exhibit periorbital erosion (J:137101)
• from 4 months of age, 75% of mice exhibit skin lesions around the mouth and nose whole 30% of mice exhibit skin lesions on the neck (J:137101)
• mice exhibit periorbital erosion (J:137101)
• from 4 months of age, 75% of mice exhibit skin lesions around the mouth and nose whole 30% of mice exhibit skin lesions on the neck (J:137101)

cellular
• mice exhibit global mesangial cell proliferation in the kidney (J:137101)
• mice exhibit global mesangial cell proliferation in the kidney (J:137101)

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus; SLE 152700 J:137101





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory