Mouse Genome Informatics
hm1
    Mta2tm1.1Yzha/Mta2tm1.1Yzha
involves: 129S4/SvJae * C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Adult Mta2tm1.1Yzha/Mta2tm1.1Yzha mice exhibit autoimmunity-related phenotypes in multiple organs

mortality/aging
• fewer than 50% of mice survive into adulthood
• about half of mice exhibit embryonic or perinatal lethality
• mice exhibit a shorter than normal life span that is shorter in female mice than in male mice
• about half of mice exhibit embryonic or perinatal lethality
• Background Sensitivity: embryonic lethality is more severe on a C57BL/6 background

immune system
• hyperproliferation follows stimulation with antiCD3 or anti-CD3 and anti-CD8 antibodies
• CD4+CD25- peripheral T cells exhibit hyperproliferation
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
• mice exhibit increased susceptibility to systemic lupus erythematosus that can be transferred by bone marrow transplant
• mice exhibit an increase in anti-dsDNA, anti-SM. anti-SSA(Ro) and anti-SSB(La) autoantibodies compared to in wild-type mice
• in more than half of mice and generally limited to the portal regions
• mice exhibit dermal and subcutaneous inflammation (panniculitis)
• some mice exhibit lymphocyte-rich chronic inflammatory cell infiltration
• chronic
• chronic spongiotic dermatitis

homeostasis/metabolism
N
• despite an increase in alanine transaminase levels, the level of aspartate aminotransferase and alkaline phosphatase levels are normal (J:137101)
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
• 40% of mice exhibit moderate or high urine protein levels with female mice exhibiting a more severe phenotype than male mice

renal/urinary system
• mice exhibit global mesangial cell proliferation in the kidney
• 40% of mice exhibit moderate or high urine protein levels with female mice exhibiting a more severe phenotype than male mice
• some mice exhibit lymphocyte-rich chronic inflammatory cell infiltration
• mice exhibit global mesangial cell proliferation in the kidney

reproductive system

liver/biliary system
• in more than half of mice and generally limited to the portal regions

skeleton

craniofacial

growth/size/body
• body size is two-thirds of normal prior to weaning and after reaching maturity

hematopoietic system
• hyperproliferation follows stimulation with antiCD3 or anti-CD3 and anti-CD8 antibodies
• CD4+CD25- peripheral T cells exhibit hyperproliferation

integument
• mice exhibit dermal and subcutaneous inflammation (panniculitis)
• chronic
• chronic spongiotic dermatitis
• in some areas mice exhibit immature and decreased hair follicles
• however, frank alopecia is not observed
• mice exhibit periorbital erosion
• from 4 months of age, 75% of mice exhibit skin lesions around the mouth and nose whole 30% of mice exhibit skin lesions on the neck

cellular
• mice exhibit global mesangial cell proliferation in the kidney

Mouse Models of Human Disease
OMIM IDRef(s)
Systemic Lupus Erythematosus; SLE 152700 J:137101