Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscamtm1Pfu mutation
(1 available);
any
Dscam mutation
(105 available)
Opn4tm1(cre)Sapa mutation
(0 available);
any
Opn4 mutation
(33 available)
|
|
|
vision/eye
|
|
• fasiculation and spacing phenotype in melanopsin positive RGCs
|
nervous system
|
|
• fasiculation and spacing phenotype in melanopsin positive RGCs
|
|
|
• fasiculation and spacing phenotype in melanopsin positive RGCs
|
cellular
|
|
• fasiculation and spacing phenotype in melanopsin positive RGCs
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(HBEGF)Awai mutation
(4 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Opn4tm1(cre)Sapa mutation
(0 available);
any
Opn4 mutation
(33 available)
|
|
|
vision/eye
|
|
• following treatment with diphtheria toxin, light pupilary reflex is lost
|
|
|
• following treatment with diphtheria toxin, 90% of melanopsin retinal ganglion cells are ablated
|
nervous system
|
|
• following treatment with diphtheria toxin, projections into the suprachiasmatic nucleus are reduced compared to in wild-type mice
|
|
|
• following treatment with diphtheria toxin, 90% of melanopsin retinal ganglion cells are ablated
|
behavior/neurological
|
N |
• despite ablation of melanopsin retinal ganglion cells following treatment with diphtheria toxin, mice exhibit normal image-forming visual responses
|
|
|
• following treatment with diphtheria toxin, light pupilary reflex is lost
|
|
|
• following treatment with diphtheria toxin, mice lose their ability to photo-entrain their circadian rhythm and mice maintain equal activity during light and dark phases unlike in wild-type mice
|
Analysis Tools