Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm2Mnz mutation
(1 available);
any
Aicda mutation
(55 available)
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cellular
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• B cells exhibit an increase in reciprocal chromosome translocations between Igh and Myc compared to in Aicdatm1Hon heterozygotes and wild-type mice
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immune system
N |
• class switching and somatic hypermutation rates are normal
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cellular
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• B cells exhibit a 3- to 6-fold increase in reciprocal chromosome translocations between Igh and Myc compared to in Aicdatm1Hon heterozygotes
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immune system
N |
• mice exhibit normal B cell development in the bone marrow, peripheral B cell numbers in the spleen, serum immunoglobulin isotypes, class switching, and somatic hypermutation rates
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