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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Itgax-TGFBR2)1Flv
transgene insertion 1, Richard A Flavell
MGI:3795208
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Eomestm1.1Twa/?
Tg(Itgax-TGFBR2)1Flv/?
involves: C3H * C57BL/6 * C57BL/6N MGI:5699436
tg2
Tg(Itgax-TGFBR2)1Flv/0 C.Cg-Tg(Itgax-TGFBR2)1Flv MGI:3795225


Genotype
MGI:5699436
cx1
Allelic
Composition
Eomestm1.1Twa/?
Tg(Itgax-TGFBR2)1Flv/?
Genetic
Background
involves: C3H * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Twa mutation (1 available); any Eomes mutation (32 available)
Tg(Itgax-TGFBR2)1Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no effect on Eomes- NK cells
• Eomes+ NK cell number is increased

hematopoietic system
• no effect on Eomes- NK cells
• Eomes+ NK cell number is increased




Genotype
MGI:3795225
tg2
Allelic
Composition
Tg(Itgax-TGFBR2)1Flv/0
Genetic
Background
C.Cg-Tg(Itgax-TGFBR2)1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-TGFBR2)1Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• size of dendritic cell (DC) compartment is normal in transgenic mice
• Flt3L treatment produces similar expansion of the DC compartment in mutants and controls
• natural killer (NK) cell homeostasis is dysregulated, with transgenic mice showing a higher frequency (10%) of NK cells in spleen vs controls (frequency = 3%)
• higher frequencies of NK cells are found in other organs, including liver and bone marrow, compared to controls
• Flt3L induces a large degree of expansion of the NK cell compartment in transgenic mice relative to wild-type controls (20% vs 5%)
• in the presence of Il-15, transgenic splenocytes cultures show a 4-fold higher frequency of NK cells than cultured wild-type cells
• Tgfb (transforming growth factor beta) suppresses NK cell differentiation into Ifng-expressing cells in controls but has no effect in transgenic NK cells
• by 3 weeks of age, mice 4-fold higher numbers of NK cells than controls; this is sustained throughout adult life; frequency of NK cells plateaus at 2 months of age
• transgenic T lymphocytes isolated from draining lymph nodes of Leishmania infection exhibit a strong TH1 response by differentiation into Ifng-expressing CD4+ T cells, while control cells show a strong TH2 response without Ifng production
• transgenic NK cells have 4-5 fold higher Ifng (interferon gamma) levels than control cells upon stimulation by different doses of Il-12; NK cells have higher intracellular Ifng levels after infection compared to control NK cells
• expression of Ifng is high and sustained in NK cells from transgenic mice
• mice have increased resistance to infection by Leishmania major compared to wild-type controls

hematopoietic system
• natural killer (NK) cell homeostasis is dysregulated, with transgenic mice showing a higher frequency (10%) of NK cells in spleen vs controls (frequency = 3%)
• higher frequencies of NK cells are found in other organs, including liver and bone marrow, compared to controls
• Flt3L induces a large degree of expansion of the NK cell compartment in transgenic mice relative to wild-type controls (20% vs 5%)
• in the presence of Il-15, transgenic splenocytes cultures show a 4-fold higher frequency of NK cells than cultured wild-type cells
• Tgfb (transforming growth factor beta) suppresses NK cell differentiation into Ifng-expressing cells in controls but has no effect in transgenic NK cells
• by 3 weeks of age, mice 4-fold higher numbers of NK cells than controls; this is sustained throughout adult life; frequency of NK cells plateaus at 2 months of age

homeostasis/metabolism
• transgenic NK cells have 4-5 fold higher Ifng (interferon gamma) levels than control cells upon stimulation by different doses of Il-12; NK cells have higher intracellular Ifng levels after infection compared to control NK cells
• expression of Ifng is high and sustained in NK cells from transgenic mice





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory