Phenotypes associated with this allele

• Allele Symbol: Tbc1d4^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3793866
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbc1d4^tm1Lex/Tbc1d4^tm1Lex	involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N	MGI:5466292

Genotype
MGI:5466292

hm1

• Allelic Composition: Tbc1d4^tm1Lex/Tbc1d4^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:191749 )

• fewer than expected mice are recovered from mating heterozygotes

homeostasis/metabolism

decreased circulating glucose level ( J:191749 )

• in random fed old male mice

• after 6 hour fasting in young and old male and female mice

decreased circulating insulin level ( J:191749 )

♂ • after 6 hour fasting in young male mice

impaired glucose tolerance ( J:191749 )

♀ • in female but not male mice

abnormal glycogen homeostasis ( J:191749 )

• glucose injection fails to increase glucose incorporation into glycogen

• however, basal levels are normal

insulin resistance ( J:191749 )

• in male and female mice

adipose tissue

increased white fat cell size ( J:191749 )

increased epididymal fat pad weight ( J:191749 )

increased parametrial fat pad weight ( J:191749 )

decreased adipocyte glucose uptake ( J:191749 )

• decreased insulin-stimulated glucose uptake

increased adipocyte glucose uptake ( J:191749 )

• 1.7-fold increase in basal glucose uptake

• increased 1.5-fold in the brown adipose tissue of glucose-injected mice

• however, white adipose tissue from mice injected with saline and glucose exhibit normal glucose uptake

muscle

decreased muscle cell glucose uptake ( J:191749 )

• decreased insulin-stimulated glucose uptake

• reduced glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus of saline-injected mice

• glucose injection fails to increase glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus unlike in wild-type mice

• however, basal glucose uptake is normal

cellular

decreased adipocyte glucose uptake ( J:191749 )

• decreased insulin-stimulated glucose uptake

increased adipocyte glucose uptake ( J:191749 )

• 1.7-fold increase in basal glucose uptake

• increased 1.5-fold in the brown adipose tissue of glucose-injected mice

• however, white adipose tissue from mice injected with saline and glucose exhibit normal glucose uptake

decreased muscle cell glucose uptake ( J:191749 )

• decreased insulin-stimulated glucose uptake

• reduced glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus of saline-injected mice

• glucose injection fails to increase glucose uptake in the gastrocnemius, tibialis anterior or extensor digitorum longus unlike in wild-type mice

• however, basal glucose uptake is normal