All Phenotypes Sfrp5<tm1Aksh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sfrp5^tm1Aksh
targeted mutation 1, Akihiko Shimono
MGI:3793862

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2^tm1Aksh Sfrp5^tm1Aksh/Sfrp5⁺ Vangl2^Lp/Vangl2⁺	involves: 129 * A * C57BL/6 * LPT/LeJ	MGI:3795553
cx2	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2⁺ Sfrp5^tm1Aksh/Sfrp5^tm1Aksh Vangl2^Lp/Vangl2⁺	involves: 129 * A * C57BL/6 * LPT/LeJ	MGI:3795555
cx3	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp5^tm1Aksh/Sfrp5^tm1Aksh Vangl2^Lp/Vangl2⁺	involves: 129 * A * C57BL/6 * LPT/LeJ	MGI:3795556
cx4	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2^tm1Aksh Sfrp5^tm1Aksh/Sfrp5⁺	involves: 129 * C57BL/6	MGI:3795554
cx5	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2^tm1Aksh Sfrp5^tm1Aksh/Sfrp5^tm1Aksh	involves: 129 * C57BL/6	MGI:3795557

Allelic Composition	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2^tm1Aksh Sfrp5^tm1Aksh/Sfrp5⁺ Vangl2^Lp/Vangl2⁺
Genetic Background	involves: 129 * A * C57BL/6 * LPT/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1^tm1Aksh mutation (0 available); any Sfrp1 mutation (17 available)
Sfrp2^tm1Aksh mutation (0 available); any Sfrp2 mutation (26 available)
Sfrp5^tm1Aksh mutation (0 available); any Sfrp5 mutation (25 available)
Vangl2^Lp mutation (2 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal rostral-caudal body axis extension ( J:135313 )

• mice exhibit an anterior-posterior elongation defect that is enhanced in the trunk relative to that observed in Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2^tm1Aksh Sfrp5^tm1Aksh/Sfrp5⁺ mice

• at late head-fold stage, mice exhibit abnormal convergence and extension

open neural tube ( J:135313 )

craniorachischisis ( J:135313 )

abnormal somite development ( J:135313 )

nervous system

open neural tube ( J:135313 )

craniorachischisis ( J:135313 )

Allelic Composition	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2⁺ Sfrp5^tm1Aksh/Sfrp5^tm1Aksh Vangl2^Lp/Vangl2⁺
Genetic Background	involves: 129 * A * C57BL/6 * LPT/LeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:135313 )

• 62% of mice exhibit spina bifida

embryo

spina bifida ( J:135313 )

• 62% of mice exhibit spina bifida

Allelic Composition	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp5^tm1Aksh/Sfrp5^tm1Aksh Vangl2^Lp/Vangl2⁺
Genetic Background	involves: 129 * A * C57BL/6 * LPT/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1^tm1Aksh mutation (0 available); any Sfrp1 mutation (17 available)
Sfrp5^tm1Aksh mutation (0 available); any Sfrp5 mutation (25 available)
Vangl2^Lp mutation (2 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:135313 )

• 13% of mice exhibit spina bifida

embryo

spina bifida ( J:135313 )

• 13% of mice exhibit spina bifida

Allelic Composition	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2^tm1Aksh Sfrp5^tm1Aksh/Sfrp5⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal rostral-caudal axis patterning ( J:135313 )

abnormal somite development ( J:135313 )

Allelic Composition	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2^tm1Aksh Sfrp5^tm1Aksh/Sfrp5^tm1Aksh
Genetic Background	involves: 129 * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:135313 )

• mice die by E12.5

embryo

abnormal rostral-caudal axis patterning ( J:135313 )

• mice exhibit more severe anterior-posterior axis defects than in Sfrp1^tm1Aksh Sfrp2^tm1Aksh homozygotes

embryonic growth retardation ( J:135313 )

open neural tube ( J:135313 )

• at E9.5

decreased somite size ( J:135313 )

• at E8.5, fused small somites are present

fused somites ( J:135313 )

• at E8.5, fused small somites are present

incomplete somite formation ( J:135313 )

nervous system

open neural tube ( J:135313 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:135313 )

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