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Allele Symbol Allele Name Allele ID |
Tg(Myh6*)140Lnwd transgene insertion 140, Leslie Leinwand MGI:3793715 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the heart weight to body weight ratio is 30% greater compared to controls
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• the heart weight to body weight ratio is 30% greater compared to controls
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice have increased mortality with only 50% survival at 8 months and less than 10% survival at 12 months
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• the heart weight to body weight ratio is 67% greater compared to controls
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• fibrosis and cellular disarray are severe in hearts of 8 month old mice
• hearts show dilated ventricular and atrial chambers with thin, fibrotic ventricular walls
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• mice have increased fractional shortening at 4 months of age but not 8 months of age
• by 8 months of age, fractional shortening has become significantly impaired to two-thirds of control
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• some mice show the signs of congestive heart failure including pulmonary and hepatic enlargement, atrial and ventricular dilation, intraperitoneal edema, and massively enlarged hearts
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• mice have increased fractional shortening at 4 months of age but not 8 months of age
• by 8 months of age, fractional shortening has become significantly impaired to two-thirds of control
|
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• the heart weight to body weight ratio is 67% greater compared to controls
|
|
• fibrosis and cellular disarray are severe in hearts of 8 month old mice
• hearts show dilated ventricular and atrial chambers with thin, fibrotic ventricular walls
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• fibrosis and cellular disarray are apparent to variable extent at 8 months of age
|
|
• fibrosis and cellular disarray are apparent to variable extent at 8 months of age
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice show increased mortality by one year compared to controls
|
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• thickening of the smooth muscle layer of the small coronary vessels
(J:36522)
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• myocardial fiber degeneration [MP:0004566] myofibrillar disarray and degeneration
• severely affected myocytes often border normal cells with frequent loss of myofibrils bordering the intercalated disc
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• hearts show evidence of small vessel coronary disease, exhibiting thickening of the smooth muscle layer of the small coronary vessels
(J:36522)
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• mice have slightly increased heart weight to body weight ratio compared to control mice
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• mutants exhibit hypertrophic cardiomyopathy including focal myocyte hypertrophy and myocellular disarray with increased matrix accumulation
(J:31537)
• hypertrophied myocytes are seen throughout the left ventricle with the largest number in the septum
(J:31537)
• cardiac hypertrophy is seen by 12 weeks of age
(J:36522)
• fibrosis and cellular disarray are apparent to variable extent at 8 months of age
(J:134706)
|
|
• left ventricular hypertrophy (35% increase) is observed by 14-15 weeks of age
(J:31537)
• hypertrophic cardiopathy in the left ventricle at 12-14 weeks of age, with focal myocyte hypertrophy and myocellular disarray with increased matrix accumulation
(J:36522)
• hypertrophy increases with age in females such than by 8 months of age, it more than doubles that observed at 12 weeks of age
(J:36522)
• males do not exhibit increased hypertrophy at 8 months of age but exhibit severe dilation
(J:36522)
• mice show modest hypertrophy of the left ventricle
(J:134706)
|
|
• males do not exhibit increased hypertrophy at 8 months of age but exhibit severe dilation, with a dilated ventricular cavity that is almond-shaped
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• mice have decreased fractional shortening at 8 and 12 months but not 4 months of age
|
|
• mice have impaired exercise tolerance on a treadmill compared to controls at 8 months of age
|
|
• thickening of the smooth muscle layer of the small coronary vessels
(J:36522)
|
|
• myocardial fiber degeneration [MP:0004566] myofibrillar disarray and degeneration
• severely affected myocytes often border normal cells with frequent loss of myofibrils bordering the intercalated disc
|
|
• left ventricular hypertrophy (35% increase) is observed by 14-15 weeks of age
(J:31537)
• hypertrophic cardiopathy in the left ventricle at 12-14 weeks of age, with focal myocyte hypertrophy and myocellular disarray with increased matrix accumulation
(J:36522)
• hypertrophy increases with age in females such than by 8 months of age, it more than doubles that observed at 12 weeks of age
(J:36522)
• males do not exhibit increased hypertrophy at 8 months of age but exhibit severe dilation
(J:36522)
• mice show modest hypertrophy of the left ventricle
(J:134706)
|
|
• mice have decreased fractional shortening at 8 and 12 months but not 4 months of age
|
|
• mice have impaired exercise tolerance on a treadmill compared to controls at 8 months of age
|
|
• mice have slightly increased heart weight to body weight ratio compared to control mice
|
|
• mutants exhibit hypertrophic cardiomyopathy including focal myocyte hypertrophy and myocellular disarray with increased matrix accumulation
(J:31537)
• hypertrophied myocytes are seen throughout the left ventricle with the largest number in the septum
(J:31537)
• cardiac hypertrophy is seen by 12 weeks of age
(J:36522)
• fibrosis and cellular disarray are apparent to variable extent at 8 months of age
(J:134706)
|
|
• left ventricular hypertrophy (35% increase) is observed by 14-15 weeks of age
(J:31537)
• hypertrophic cardiopathy in the left ventricle at 12-14 weeks of age, with focal myocyte hypertrophy and myocellular disarray with increased matrix accumulation
(J:36522)
• hypertrophy increases with age in females such than by 8 months of age, it more than doubles that observed at 12 weeks of age
(J:36522)
• males do not exhibit increased hypertrophy at 8 months of age but exhibit severe dilation
(J:36522)
• mice show modest hypertrophy of the left ventricle
(J:134706)
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hypertrophic cardiomyopathy 14 | DOID:0110320 |
OMIM:613251 |
J:31537 , J:36522 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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