Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Celsr3tm2Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Foxg1tm1(cre)Skm mutation
(2 available);
any
Foxg1 mutation
(28 available)
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nervous system
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• despite normal expression in the dorsal thalamus, the three components of the internal capsule (corticothalamic axons, thalamocortical axons and subcerebral projections) are abnormal
• unlike in control mice, no thalamic fibers turn towards the striatum
• however, corticothalamic axons grow towards the ventral telencephalon
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Celsr3tm2Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Tg(Nkx2-1-cre)1Wdr mutation
(0 available)
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nervous system
N |
• the brain internal capsule develops normally
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Celsr3tm2Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Emx1tm1(cre)Krj mutation
(2 available);
any
Emx1 mutation
(34 available)
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nervous system
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• only diminutive bundles originating from the olfactory nuclei run caudally and turn but never cross the midline unlike in control mice (double heterozygotes)
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• subdural projections develop abnormally
• however, corticothalamic and thalamicortical axons are normal
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Celsr3tm2Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Tg(Gsx2-icre)1Kess mutation
(1 available)
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nervous system
N |
• the brain internal capsule develops normally
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Celsr3tm2Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Tg(Gsx2-icre)1Kess mutation
(1 available)
Tg(Nkx2-1-cre)1Wdr mutation
(0 available)
|
|
|
nervous system
N |
• the brain internal capsule develops normally
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Celsr3tm2Agof mutation
(0 available);
any
Celsr3 mutation
(122 available)
Tg(mI56i-cre,EGFP)1Kc mutation
(1 available)
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nervous system
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• the thalamocortical axons aberrantly run through the pallidum and amygdala
• while corticofugal fibers cross the pallial-subpallial boundary and enter the lateral part of the basal forebrain, they fail to progress and spiral in a disordered manner
• both corticothalamic and thalamocortial axons are abnormal
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