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Allele Symbol Allele Name Allele ID |
Klrk1tm1Dhr targeted mutation 1, David H Raulet MGI:3790957 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• modestly increased functional activity
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• modestly increased functional activity
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• NK cells are partially impaired in their ability to lyse target cells expressing NK2GD
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• NK cells are partially impaired in their ability to lyse target cells expressing NK2GD
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• early-arising, massive prostate tumors that weight more than 2.7 grams are three times more frequent in these mice than in littermate controls that carry just the transgene
• the incidence of mice with early arising tumors is 27.9%
• these tumors exhibit nearly uniform lesions of poorly differentiated cells that are highly malignant
• tumors that arise later have cells that are well differentiated and less aggressive
• the mean weight of prostates at necropsy significantly exceeds that of controls
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• early-arising, massive prostate tumors that weight more than 2.7 grams are three times more frequent in these mice than in littermate controls that carry just the transgene
• the incidence of mice with early arising tumors is 27.9%
• these tumors exhibit nearly uniform lesions of poorly differentiated cells that are highly malignant
• tumors that arise later have cells that are well differentiated and less aggressive
• the mean weight of prostates at necropsy significantly exceeds that of controls
|
|
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• early-arising, massive prostate tumors that weight more than 2.7 grams are three times more frequent in these mice than in littermate controls that carry just the transgene
• the incidence of mice with early arising tumors is 27.9%
• these tumors exhibit nearly uniform lesions of poorly differentiated cells that are highly malignant
• tumors that arise later have cells that are well differentiated and less aggressive
• the mean weight of prostates at necropsy significantly exceeds that of controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lymphomas develop significantly earlier in these mice than in mice carrying the transgene on a wild-type background
• the mean time of onset is 7 weeks earlier than in the control group with all mice have detectable tumors by 30 weeks of age
• the tumors consist of a mix pre-B and B cells lymphomas
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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