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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tlx3tm1(cre)Qima
targeted mutation 1, Qiufu Ma
MGI:3789185
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tlx3tm1(cre)Qima/Tlx3+
involves: 129/Sv MGI:4440934
cn2
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tlx3tm1(cre)Qima/Tlx3+
involves: 129X1/SvJ MGI:3810319


Genotype
MGI:4440934
cn1
Allelic
Composition
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tlx3tm1(cre)Qima/Tlx3+
Genetic
Background
involves: 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm2.1Meg mutation (0 available); any Bhlhe22 mutation (7 available)
Tlx3tm1(cre)Qima mutation (0 available); any Tlx3 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice do not show skin lesions or heightened itch responses to pruritic agents

integument
N
• mice do not show skin lesions in response to selective deletion in excitatory neurons in dorsal horn




Genotype
MGI:3810319
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tlx3tm1(cre)Qima/Tlx3+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (343 available)
Tlx3tm1(cre)Qima mutation (0 available); any Tlx3 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 40% of mice develop focal medulloblastomas and have a mean survival of 102 days

mortality/aging
• mice survive 102 days

neoplasm
• 40% of mice develop focal medulloblastomas and have a mean survival of 102 days

Mouse Models of Human Disease
OMIM ID Ref(s)
Medulloblastoma; MDB 155255 J:139574





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory