All Phenotypes Rspo1<tm1.1Ktom> MGI Mouse

decreased oocyte number ( J:133934 )

• newborn females have reduced numbers of oocytes though a few are able to survive to form follicles

decreased oocyte number ( J:133934 )

• newborn females have reduced numbers of oocytes though a few are able to survive to form follicles

• the number of follicles are reduced in both prepubertal and pubertal females

abnormal ovary development ( J:133934 )

• at E16.5, increased levels of apoptosis for meiotic germ cells are observed throughout the ovary

• the emergence of sex cord-like structures can be observed in the ovaries at birth

• at three weeks of age sex cords similar to seminiferous tubes can be observed along with healthy maturing follicles

• within these tubules, cells are observed that resemble Sertoli cells in their morphological characteristics and molecular markers

• by 7 weeks of age there are areas in the ovary that lack follicles

abnormal ovary secretion ( J:133934 )

• 1000pg/mg protein, about 1/10^th of what is found in newborn testis of wild-type mice while none is found in wild-type ovaries

pseudohermaphroditism ( J:133934 )

• the ovaries are surrounded by highly coiled ductal structures resembling the male epididymis

• in addition, vas deferens-like ducts tracked down the uterine horns and vagina

• structures resembling seminal vesicles sometimes form on the wall of the upper vagina

• this pseudohermaphroditism occurs with 100% penetrance though 11% of mice will have one of their two reproductive tracts be phenotypically normal

reduced female fertility ( J:133934 )

• only 1 of 6 females had litters after 1 month of continuous mating