All Phenotypes Tg(Dmp1-cre)1Jqfe MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Dmp1-cre)1Jqfe
transgene insertion 1, Jian Q Feng
MGI:3784520

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lrp5^tm3.1Mawa/Lrp5^tm3.1Mawa Tg(Dmp1-cre)1Jqfe/0	involves: 129 * C57BL/6J * FVB/N	MGI:5014233
cn2	Tnfsf11^tm1.1Htaka/Tnfsf11^tm1.2Htaka Tg(Dmp1-cre)1Jqfe/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N	MGI:5297086
cn3	Lrp5^tm1Mawa/Lrp5⁺ Tg(Dmp1-cre)1Jqfe/0	involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * FVB/N	MGI:5014225
cn4	Lrp5^tm2Mawa/Lrp5⁺ Tg(Dmp1-cre)1Jqfe/0	involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * FVB/N	MGI:5014223
cn5	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(Dmp1-cre)1Jqfe/0	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB	MGI:5297380

Allelic Composition	Lrp5^tm3.1Mawa/Lrp5^tm3.1Mawa Tg(Dmp1-cre)1Jqfe/0
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm3.1Mawa mutation (0 available); any Lrp5 mutation (81 available)
Tg(Dmp1-cre)1Jqfe mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased bone mass ( J:172746 )

Allelic Composition	Tnfsf11^tm1.1Htaka/Tnfsf11^tm1.2Htaka Tg(Dmp1-cre)1Jqfe/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dmp1-cre)1Jqfe mutation (4 available)
Tnfsf11^tm1.1Htaka mutation (0 available); any Tnfsf11 mutation (30 available)
Tnfsf11^tm1.2Htaka mutation (0 available); any Tnfsf11 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:177557 )

N	• mice exhibit normal tooth eruption

decreased osteoclast cell number ( J:177557 )

increased bone volume ( J:177557 )

• at 12 weeks of age

increased trabecular bone volume ( J:177557 )

• filling the bone marrow cavity at 12 weeks of age

increased bone mass ( J:177557 )

• with age beginning postnatally

osteopetrosis ( J:177557 )

• severe postnatally

abnormal cartilage morphology ( J:177557 )

• mice exhibit cartilage remnants unlike control mice

abnormal bone ossification ( J:177557 )

• bone formation is decreased compared to in control mice

decreased bone resorption ( J:177557 )

immune system

decreased osteoclast cell number ( J:177557 )

growth/size/body

growth/size/body region phenotype ( J:177557 )

N	• mice exhibit normal growth

hematopoietic system

decreased osteoclast cell number ( J:177557 )

Allelic Composition	Lrp5^tm1Mawa/Lrp5⁺ Tg(Dmp1-cre)1Jqfe/0
Genetic Background	involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm1Mawa mutation (1 available); any Lrp5 mutation (81 available)
Tg(Dmp1-cre)1Jqfe mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone mass ( J:172746 )

Allelic Composition	Lrp5^tm2Mawa/Lrp5⁺ Tg(Dmp1-cre)1Jqfe/0
Genetic Background	involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm2Mawa mutation (2 available); any Lrp5 mutation (81 available)
Tg(Dmp1-cre)1Jqfe mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone mass ( J:172746 )

Allelic Composition	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(Dmp1-cre)1Jqfe/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dmp1-cre)1Jqfe mutation (4 available)
Tnfsf11^tm1.1Caob mutation (1 available); any Tnfsf11 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:177558 )

N	• mice exhibit normal tooth eruption and growth plates

abnormal bone structure ( J:177558 )

• mice suspended by their tails for 3 weeks are protected from loss of bone and changes in cancellous architecture compared with similarly treated wild-type mice

abnormal osteoclast cell number ( J:177558 )

• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice

decreased osteoclast cell number ( J:177558 )

increased bone mineral density of vertebrae ( J:177558 )

• BMD increases progressively in the spine

increased bone mineral density of femur ( J:177558 )

• BMD increases progressively in the femur

increased trabecular bone volume ( J:177558 )

• at 6 months of age in the femur and spine

decreased compact bone thickness ( J:177558 )

• in mice suspended by their tails for 3 weeks

increased bone trabecular spacing ( J:177558 )

• mice suspended by their tails for 3 weeks exhibit increased trabecular spacing compared with similarly treated wild-type mice

immune system

abnormal osteoclast cell number ( J:177558 )

• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice

decreased osteoclast cell number ( J:177558 )

hematopoietic system

abnormal osteoclast cell number ( J:177558 )

• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice

decreased osteoclast cell number ( J:177558 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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