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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(GFAP-APOE_i4)#Hol
transgene insertion, David M Holtzman
MGI:3784297
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Apoetm1Unc/Apoetm1Unc
Tg(GFAP-APOE_i4)#Hol/0
B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)#Hol MGI:3784380
cx2
Apoetm1Unc/Apoetm1Unc
Tg(APPV717F)109Ili/0
Tg(GFAP-APOE_i4)#Hol/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3784383


Genotype
MGI:3784380
cx1
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Tg(GFAP-APOE_i4)#Hol/0
Genetic
Background
B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)#Hol
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (21 available); any Apoe mutation (64 available)
Tg(GFAP-APOE_i4)#Hol mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice require more time to habituate to a novel environment compared to wild-type mice
• at 14 to 17 months of age, mice did not perform as well as Apoetm1Unc homozygotes and Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc mice in a rotating holeboard test
• however, mice perform as well as wild-type mice in a rotating holeboard test
• mice exhibit an impairment in working memory in a radial arm maze test compared to wild-type mice
• compared to wild-type mice
• mice spend less time than wild-type mice and Apoetm1Unc homozygotes in the center of an open field
• mice exhibit increased numbers of fine movement (not related to ambulation) compared to wild-type mice




Genotype
MGI:3784383
cx2
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Tg(APPV717F)109Ili/0
Tg(GFAP-APOE_i4)#Hol/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (21 available); any Apoe mutation (64 available)
Tg(APPV717F)109Ili mutation (0 available)
Tg(GFAP-APOE_i4)#Hol mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• by 15 to 18 months, 60% of mice exhibit plaques in the hippocampus (J:127846)
• the amount of amyloid deposited is more than in Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc mice but much less than in Tg(APPV717F)109Ili Apoetm1Unc/Apoetm1Unc mice (J:127846)
• plaques are observed in the outer molecular layer of the dentate gyrus and the stratum oriens and radiatum of the hippocampus (J:127846)
• mice exhibit fibrillar plaques in the outer molecular layer of the dentate gyrus (J:127846)
• 55.6% of mice exposed to traumatic brain injury (TBI) at 9 to 10 months of age exhibit amyloid plaques by 12 to 13 months of age while mice not exposed to TBI do not exhibit plaques until 15 months of age (J:133058)
• mice exhibit increased plaque formation and severity following TBI compared to in similarly treated Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc mice (J:133058)
• 44% of mice exhibit thioflavine-S+ amyloid staining (fibrillar amyloid) in the molecular layer unlike in Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc and Tg(APPV717F)109Ili Apoetm1Unc/Apoetm1Unc mice (J:133058)

homeostasis/metabolism
• by 15 to 18 months, 60% of mice exhibit plaques in the hippocampus (J:127846)
• the amount of amyloid deposited is more than in Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc mice but much less than in Tg(APPV717F)109Ili Apoetm1Unc/Apoetm1Unc mice (J:127846)
• plaques are observed in the outer molecular layer of the dentate gyrus and the stratum oriens and radiatum of the hippocampus (J:127846)
• mice exhibit fibrillar plaques in the outer molecular layer of the dentate gyrus (J:127846)
• 55.6% of mice exposed to traumatic brain injury (TBI) at 9 to 10 months of age exhibit amyloid plaques by 12 to 13 months of age while mice not exposed to TBI do not exhibit plaques until 15 months of age (J:133058)
• mice exhibit increased plaque formation and severity following TBI compared to in similarly treated Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc mice (J:133058)
• 44% of mice exhibit thioflavine-S+ amyloid staining (fibrillar amyloid) in the molecular layer unlike in Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc and Tg(APPV717F)109Ili Apoetm1Unc/Apoetm1Unc mice (J:133058)





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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory