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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lystbg-2Btlr
beige 2 Bruce Beutler
MGI:3779040
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lystbg-2Btlr/Lystbg-2Btlr C57BL/6J-Lystbg-2Btlr MGI:3779043


Genotype
MGI:3779043
hm1
Allelic
Composition
Lystbg-2Btlr/Lystbg-2Btlr
Genetic
Background
C57BL/6J-Lystbg-2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lystbg-2Btlr mutation (0 available); any Lyst mutation (109 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• the coats of mice homozygous for this mutation are a subtle gray color

immune system
• NK cells from homozygous mutatant mice fail to degranulate following antibody stimulation of NKp46 or Ly49H receptors or after exposure to YAC-1 cells or PMA/ionomycin
• homozygous mutant mice are highly susceptible to infection by mouse cytomegalovirus (MCMV)

integument
• the coats of mice homozygous for this mutation are a subtle gray color

hematopoietic system
• NK cells from homozygous mutatant mice fail to degranulate following antibody stimulation of NKp46 or Ly49H receptors or after exposure to YAC-1 cells or PMA/ionomycin

Mouse Models of Human Disease
OMIM ID Ref(s)
Chediak-Higashi Syndrome; CHS 214500 J:133617





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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory