pigmentation

diluted coat color ( J:133617 )

• the coats of mice homozygous for this mutation are a subtle gray color

immune system

abnormal NK cell physiology ( J:133617 )

• NK cells from homozygous mutatant mice fail to degranulate following antibody stimulation of NKp46 or Ly49H receptors or after exposure to YAC-1 cells or PMA/ionomycin

increased susceptibility to viral infection ( J:133617 )

• homozygous mutant mice are highly susceptible to infection by mouse cytomegalovirus (MCMV)

integument

diluted coat color ( J:133617 )

• the coats of mice homozygous for this mutation are a subtle gray color

Mouse Models of Human Disease		OMIM ID	Ref(s)
Chediak-Higashi Syndrome; CHS		214500	J:133617