About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky
targeted mutation 3, Klaus Rajewsky
MGI:3778920
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sor+
Tg(CD2-icre)4Kio/0
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:3783574
cn2
Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky
Tg(CD2-icre)4Kio/0
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:3783575


Genotype
MGI:3783574
cn1
Allelic
Composition
Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sor+
Tg(CD2-icre)4Kio/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
Tg(CD2-icre)4Kio mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit more CD19+B220loCD5+CD43+CD23- B-1a cells in the spleen and peritoneal cavity compared to in wild-type mice

hematopoietic system
• mice exhibit more CD19+B220loCD5+CD43+CD23- B-1a cells in the spleen and peritoneal cavity compared to in wild-type mice




Genotype
MGI:3783575
cn2
Allelic
Composition
Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky
Tg(CD2-icre)4Kio/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
Tg(CD2-icre)4Kio mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• spleens and lymph nodes are enlarged up to 30-fold in terms of weight and cell number compared to in wild-type mice
• spleens and lymph nodes are enlarged up to 30-fold in terms of weight and cell number compared to in wild-type mice

cellular
• B-2 cell proliferation is enhanced following activation with anti-IgM or lipopolysaccharides unlike in wild-type cells

mortality/aging
• all mice die by 55 weeks of age

immune system
N
• despite increased immunoglobulin, cytokine levels in the blood are normal
• spleens and lymph nodes are enlarged up to 30-fold in terms of weight and cell number compared to in wild-type mice
• spleens and lymph nodes are enlarged up to 30-fold in terms of weight and cell number compared to in wild-type mice
• prior to 14 weeks of age, mice exhibit a 2-fold higher percentage of thymocytes at the double negative stage compared to in wild-type mice
• however, the total number of thymocytes is unchanged
• at 5 weeks of age
• in the spleen and peripheral lymph nodes
• mice exhibit more CD19+B220loCD5+CD43+CD23- B-1a cells in the spleen and peritoneal cavity compared to in wild-type mice
• spleen and lymph node B cells exhibit increased cell size compared to in wild-type mice
• CD4+ T cells exhibit increased proliferation and survival following stimulation with CD3 alone unlike wild-type cells
• the spleen marginal zone is disrupted unlike in wild-type mice
• spleens and lymph nodes are enlarged up to 30-fold in terms of weight and cell number compared to in wild-type mice
• spleens and lymph nodes are enlarged up to 30-fold in terms of weight and cell number compared to in wild-type mice
• mice exhibit massive infiltration of lymphocytes into the salivary glands and lungs with some infiltration of the kidneys unlike in wild-type mice
• B cells are more resistance than in wild-type mice to Fas-mediated cell death following activation
• activated B cells exhibit enhanced proliferation and survival compared to wild-type cells
• B-2 cell proliferation is enhanced following activation with anti-IgM or lipopolysaccharides unlike in wild-type cells
• 4- to 6-fold at 8 to 12 weeks of age
• 4- to 6-fold at 8 to 12 weeks of age
• 4- to 6-fold at 8 to 12 weeks of age
• 4- to 6-fold at 8 to 12 weeks of age
• more CD4+ T cells produce IFN-gamma and IL-10 but not IL-4 or TNF than wild-type cells
• CD4+T cells from older mice produce more IFN-gamma and IL-10 than CD4+ T cells from younger mice
• activated T cells exhibit enhanced proliferation and survival compared to wild-type cells

renal/urinary system
• a subset of mice show marked accumulation of IgG and the C3d component of complement in the mesangium and segmentally in the periphery of glomeruli
• mice exhibit mesangial expansion unlike in wild-type mice
• mice exhibit enlarged renal glomeruli with hypercellularity and mesangial expansion unlike in wild-type mice
• in some mice

homeostasis/metabolism

hematopoietic system
• spleens and lymph nodes are enlarged up to 30-fold in terms of weight and cell number compared to in wild-type mice
• spleens and lymph nodes are enlarged up to 30-fold in terms of weight and cell number compared to in wild-type mice
• prior to 14 weeks of age, mice exhibit a 2-fold higher percentage of thymocytes at the double negative stage compared to in wild-type mice
• however, the total number of thymocytes is unchanged
• at 5 weeks of age
• in the spleen and peripheral lymph nodes
• mice exhibit more CD19+B220loCD5+CD43+CD23- B-1a cells in the spleen and peritoneal cavity compared to in wild-type mice
• spleen and lymph node B cells exhibit increased cell size compared to in wild-type mice
• CD4+ T cells exhibit increased proliferation and survival following stimulation with CD3 alone unlike wild-type cells
• the spleen marginal zone is disrupted unlike in wild-type mice
• B cells are more resistance than in wild-type mice to Fas-mediated cell death following activation
• activated B cells exhibit enhanced proliferation and survival compared to wild-type cells
• B-2 cell proliferation is enhanced following activation with anti-IgM or lipopolysaccharides unlike in wild-type cells
• 4- to 6-fold at 8 to 12 weeks of age
• 4- to 6-fold at 8 to 12 weeks of age
• 4- to 6-fold at 8 to 12 weeks of age
• 4- to 6-fold at 8 to 12 weeks of age
• more CD4+ T cells produce IFN-gamma and IL-10 but not IL-4 or TNF than wild-type cells
• CD4+T cells from older mice produce more IFN-gamma and IL-10 than CD4+ T cells from younger mice
• activated T cells exhibit enhanced proliferation and survival compared to wild-type cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/12/2022
MGI 6.17
The Jackson Laboratory