All Phenotypes Vangl1<Gt(XL802)Byg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vangl1^Gt(XL802)Byg
gene trap XL802, BayGenomics
MGI:3778822

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3778823
cx2	Vangl1^Gt(XL802)Byg/Vangl1⁺ Vangl2^ska17/Vangl2⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J	MGI:4941950
cx3	Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg Vangl2^Lp/Vangl2⁺	involves: 129P2/OlaHsd * A	MGI:4819599
cx4	Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg Vangl2^tm1.2Yy/Vangl2^tm1.2Yy	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4819601
cx5	Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg Vangl2^tm1.2Yy/Vangl2⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4819600
cx6	Vangl1^Gt(XL802)Byg/Vangl1⁺ Vangl2^Lp/Vangl2⁺	involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ	MGI:3778824

Allelic Composition	Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl1^Gt(XL802)Byg mutation (1 available); any Vangl1 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Abnormal orientation of hair cells of the cochlea in Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg embryos

hearing/vestibular/ear

abnormal orientation of cochlear hair cell stereociliary bundles ( J:132697 )

• modest but significant misorientation in all hair cell layers

• however, the number and organization of hair cell rows is not different from wild-type controls

cardiovascular system

cardiovascular system phenotype ( J:132697 )

N	• unlike mice homozygous for Vangl2^Lp alone, nor outflow tract abnormalities are detected

nervous system

nervous system phenotype ( J:132697 )

N	• unlike mice with mutations in Vangl2, no neural tube defects are detected

abnormal orientation of cochlear hair cell stereociliary bundles ( J:132697 )

• modest but significant misorientation in all hair cell layers

• however, the number and organization of hair cell rows is not different from wild-type controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	neural tube defect	DOID:0080074	OMIM:301410 OMIM:601634	J:132697

Allelic Composition	Vangl1^Gt(XL802)Byg/Vangl1⁺ Vangl2^ska17/Vangl2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl1^Gt(XL802)Byg mutation (1 available); any Vangl1 mutation (85 available)
Vangl2^ska17 mutation (0 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:169664 )

• no tail, neural tube or eyelid fusion defects are detected

Allelic Composition	Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg Vangl2^Lp/Vangl2⁺
Genetic Background	involves: 129P2/OlaHsd * A

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl1^Gt(XL802)Byg mutation (1 available); any Vangl1 mutation (85 available)
Vangl2^Lp mutation (2 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

vagina atresia ( J:162640 )

female infertility ( J:162640 )

nervous system

abnormal cochlear inner hair cell morphology ( J:162640 )

• inner hair cells are misoriented compared to in wild-type mice

abnormal cochlear outer hair cell morphology ( J:162640 )

• outer hair cells are misoriented compared to in wild-type mice

limbs/digits/tail

short tail ( J:162640 )

• compared with Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg Vangl2^tm1.2Yy/Vangl2⁺

hearing/vestibular/ear

abnormal cochlear inner hair cell morphology ( J:162640 )

• inner hair cells are misoriented compared to in wild-type mice

abnormal cochlear outer hair cell morphology ( J:162640 )

• outer hair cells are misoriented compared to in wild-type mice

Allelic Composition	Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg Vangl2^tm1.2Yy/Vangl2^tm1.2Yy
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl1^Gt(XL802)Byg mutation (1 available); any Vangl1 mutation (85 available)
Vangl2^tm1.2Yy mutation (0 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryonic cilium location or orientation ( J:162640 )

• positioning of the posterior notochord (node) cilia is randomized unlike in wild-type mice

• in the posterior notochord (node), cell density is slightly reduced and cilia localization is altered compared to in wild-type mice

abnormal motile primary cilium physiology ( J:162640 )

• nodal flow produces swirling vortices and time to cross the posterior notochord (node) is lengthened compared to in wild-type mice

• unilateral nodal flow in the posterior notochord (node) is compromised compared to in wild-type mice

• however, cilia in the posterior notochord beat at the same speed and direction as in wild-type mice

abnormal embryo turning ( J:162640 )

• embryos fail to turn unlike wild-type mice

abnormal notochord morphology ( J:162640 )

• cell density and the number of posteriorly localized basal bodies in the posterior notochord (node) are decreased compared to in wild-type mice

growth/size/body

abnormal prenatal body size ( J:162640 )

• embryos exhibit a reduction in length to width ratio compared with wild-type mice

heterotaxia ( J:162640 )

• mice exhibit left-right asymmetry defects compared with wild-type mice

• however, nodal cilia appear normal

left pulmonary isomerism ( J:162640 )

• mild

nervous system

abnormal cochlear inner hair cell morphology ( J:162640 )

• inner hair cells are misoriented compared to in wild-type mice

abnormal cochlear outer hair cell morphology ( J:162640 )

• outer hair cells are misoriented compared to in wild-type mice

cardiovascular system

failure of heart looping ( J:162640 )

respiratory system

left pulmonary isomerism ( J:162640 )

• mild

hearing/vestibular/ear

abnormal cochlear inner hair cell morphology ( J:162640 )

• inner hair cells are misoriented compared to in wild-type mice

abnormal cochlear outer hair cell morphology ( J:162640 )

• outer hair cells are misoriented compared to in wild-type mice

cellular

abnormal embryonic cilium location or orientation ( J:162640 )

• positioning of the posterior notochord (node) cilia is randomized unlike in wild-type mice

• in the posterior notochord (node), cell density is slightly reduced and cilia localization is altered compared to in wild-type mice

abnormal motile primary cilium physiology ( J:162640 )

• nodal flow produces swirling vortices and time to cross the posterior notochord (node) is lengthened compared to in wild-type mice

• unilateral nodal flow in the posterior notochord (node) is compromised compared to in wild-type mice

• however, cilia in the posterior notochord beat at the same speed and direction as in wild-type mice

Allelic Composition	Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg Vangl2^tm1.2Yy/Vangl2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cochlear outer hair cell morphology ( J:162640 )

• outer hair cells in rows 3 and 2 are misoriented compared to in wild-type mice

limbs/digits/tail

long tail ( J:162640 )

• compared with Vangl2^Lp/Vangl2^Lp Vangl2^tm1.2Yy/Vangl2⁺

hearing/vestibular/ear

abnormal cochlear outer hair cell morphology ( J:162640 )

• outer hair cells in rows 3 and 2 are misoriented compared to in wild-type mice

Allelic Composition	Vangl1^Gt(XL802)Byg/Vangl1⁺ Vangl2^Lp/Vangl2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Vangl1^Gt(XL802)Byg/Vangl1⁺ Vangl2^Lp/Vangl2⁺ and Vangl2^Lp/Vangl2^Lp embryos exhibit aberrant right subclavian artery

mortality/aging

perinatal lethality, incomplete penetrance ( J:132697 )

• fewer than expected double heterozygotes are found at weaning (20% rather than the expected 50%) given the presence of craniorachischisis late embryonic lethality is probably the cause of the distorted ratio

nervous system

craniorachischisis ( J:132697 )

• seen in over 60% of double heterozygotes at E13.5 - E18.5

• phenotype is as severe as in mice homozygous for Vangl2^Lp alone

• no obvious neural tube defects are seen in surviving mice

abnormal cochlear hair cell stereociliary bundle morphology ( J:132697 )

• profoundly distorted

abnormal orientation of inner hair cell stereociliary bundles ( J:132697 )

• 20% of inner hair cell bundles are misoriented

abnormal orientation of outer hair cell stereociliary bundles ( J:132697 )

• some bundles in all 3 layers are misoriented especially at the apical turn (over 50% of bundles in OHC1, 65% in OHC2, over 80% in OHC3)

• vertices are randomly oriented with rotation angles of 40 - 180 degrees

cardiovascular system

cardiovascular system phenotype ( J:132697 )

N	• unlike mice homozygous for Vangl2^Lp alone, no outflow tract abnormalities are detected in double heterozygotes

retroesophageal right subclavian artery ( J:132697 )

• at E14.5, the right subclavian artery is positioned dorsal to the esophagus

hearing/vestibular/ear

abnormal cochlea morphology ( J:132697 )

• reduced in size at E18.5 in mice displaying craniorachischisis

abnormal cochlear hair cell stereociliary bundle morphology ( J:132697 )

• profoundly distorted

abnormal orientation of inner hair cell stereociliary bundles ( J:132697 )

• 20% of inner hair cell bundles are misoriented

abnormal orientation of outer hair cell stereociliary bundles ( J:132697 )

• some bundles in all 3 layers are misoriented especially at the apical turn (over 50% of bundles in OHC1, 65% in OHC2, over 80% in OHC3)

• vertices are randomly oriented with rotation angles of 40 - 180 degrees

limbs/digits/tail

curly tail ( J:132697 )

embryo

craniorachischisis ( J:132697 )

• seen in over 60% of double heterozygotes at E13.5 - E18.5

• phenotype is as severe as in mice homozygous for Vangl2^Lp alone

• no obvious neural tube defects are seen in surviving mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neural tube defect		DOID:0080074	OMIM:301410 OMIM:601634	J:132697

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23