Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncstntm1.1Sud mutation
(0 available);
any
Ncstn mutation
(33 available)
Tg(Camk2a-cre)1Shn mutation
(0 available)
|
|
|
nervous system
|
N |
• brain morphology is normal at 2 months
|
|
|
• progressive as early as 2 months
|
|
|
• at 6 and 9 months, mice exhibit cortical atrophy with loss of cortical neurons unlike wild-type mice
|
|
|
• at 6 and 9 months, neocortical volume is decreased compared to in wild-type mice
|
|
|
• progressive as early as 2 months
|
|
|
• mice exhibit age-dependent dendrite loss unlike wild-type mice
|
behavior/neurological
|
N |
• mice exhibit normal swimming abilities, activity levels, and coordination
|
|
|
• long term-term associative fear memory in a contextual conditioning assay is impaired in an age-dependent manner compared to in wild-type mice
|
|
|
• in a Morris water maze, mice exhibit age-dependent impaired spatial learning compared with wild-type mice
|
|
|
• in a Morris water maze with hidden platform, mice exhibit age-dependent impaired spatial memory compared with wild-type mice
|
cellular
|
|
• progressive as early as 2 months
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm2Shn mutation
(1 available);
any
Psen1 mutation
(46 available)
Psen1tm4.1Shn mutation
(0 available);
any
Psen1 mutation
(46 available)
Psen2tm1Haa mutation
(0 available);
any
Psen2 mutation
(31 available)
Tg(Camk2a-cre)1Shn mutation
(0 available)
|
|
|
nervous system
|
|
• in the neocortex and hippocampus
|
|
|
• 31.5% reduction in cortical volume at 18 months of age
|
|
|
• increase in apoptosis in the neocortex
|
|
|
• 22.1% reduction in neuron number in the cerebral cortex at 18 months of age
|
|
|
• mice exhibit age-dependent neurodegeneration throughout the cerebral cortex
|
hematopoietic system
|
|
• in the neocortex and hippocampus
|
immune system
|
|
• in the neocortex and hippocampus
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm2Shn mutation
(1 available);
any
Psen1 mutation
(46 available)
Tg(Camk2a-cre)1Shn mutation
(0 available)
|
|
|
behavior/neurological
|
|
• mice show mild defect in spatial learning
|
|
|
• mice have mild but significant impairment in spatial learning and memory
• in the Morris water maze paradigm, mutants and wild-type mice show improvements in performance for the initial 7 days of training, but for the last 3-5 days, mutant performance plateaus while control mice continue to improve in finding the hidden platform
• in probe trials, mutants diplay fewer crossings of the target quadrant after 10 days of training compared to wild-type mice
• similar results are obtained when platform position is changed and test is repeated
|
nervous system
|
N |
• examination of brains at P18, 20, 22, and 3 months shows no gross abnormalities
• no increase in apoptosis is observed at any ages examined
• normal synaptic transmission and plasticity in the Schaeffer collateral pathway are observed
|
|
|
• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated
|
homeostasis/metabolism
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm2.1Shn mutation
(0 available);
any
Psen1 mutation
(46 available)
Psen1tm2Shn mutation
(1 available);
any
Psen1 mutation
(46 available)
Tg(Camk2a-cre)1Shn mutation
(0 available)
|
|
|
behavior/neurological
|
|
• mice show mild defect in spatial learning
|
|
|
• mice have mild but significant impairment in spatial learning and memory
• in the Morris water maze paradigm, mutants and wild-type mice show improvements in performance for the initial 7 days of training, but for the last 3-5 days, mutant performance plateaus while control mice continue to improve in finding the hidden platform
• in probe trials, mutants diplay fewer crossings of the target quadrant after 10 days of training compared to wild-type mice
• similar results are obtained when platform position is changed and test is repeated
|
nervous system
|
N |
• examination of brains at P18, 20, 22, and 3 months shows no gross abnormalities
• no increase in apoptosis is observed at any ages examined
• normal synaptic transmission and plasticity in the Schaeffer collateral pathway are observed
|
|
|
• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated
|
homeostasis/metabolism
Analysis Tools