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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ovol2tm1Sito
targeted mutation 1, Seiji Ito
MGI:3777011
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ovol2tm1Sito/Ovol2tm1Sito involves: 129P2/OlaHsd * C57BL/6J MGI:3777775


Genotype
MGI:3777775
hm1
Allelic
Composition
Ovol2tm1Sito/Ovol2tm1Sito
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ovol2tm1Sito mutation (1 available); any Ovol2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos die in utero between E9.5 and E10.5, due to abnormal cardiovascular development

embryo
• at E8.5 and E9.5
• at E9.5, embryos are smaller than wild-type
• at E9.5, only first branchial arch is observed in mutants, not three
• at E9.5 embryos display open head folds
• mutant embryos show normal establishment of allantoic vessels and differentiation of trophoblast cells, but fail to support normal branching or elongation of the vessels and labyrinthine layer in the placenta
• at E9.5, the invasion of allantoic vessels into the labyrinth layer and the number of fetal blood cells are reduced in the mutant placenta
• at E10.5, the invasion process is retracted, and only a few fetal blood cells are found in the chorion
• at E9.5, yolk sac fails to develop large vitelline vessels
• at E9.5, vascular remodeling in the yolk sac does not occur
• at E9.5, mutant yolk sacs display the same primary vascular plexus observed at E8.5

growth/size/body
• at E8.5 and E9.5
• at E9.5, embryos are smaller than wild-type

cardiovascular system
• typical intersomitic vessels are absent
• mutant embryos show normal establishment of allantoic vessels and differentiation of trophoblast cells, but fail to support normal branching or elongation of the vessels and labyrinthine layer in the placenta
• at E9.5, the invasion of allantoic vessels into the labyrinth layer and the number of fetal blood cells are reduced in the mutant placenta
• at E10.5, the invasion process is retracted, and only a few fetal blood cells are found in the chorion
• at E9.5, blood vessels throughout entire embryo are disorganized
• typical intersomitic vessels are absent, and numerous disorganized vessels are found in the caudal region
• vascular formation in head region and heart endocardium remains undeveloped at E8.5 and E9.5
• at E9.5, yolk sac fails to develop large vitelline vessels
• at E9.5, mutant hearts show a lack of myocardial trabeculation
• at E8.5, the aortic sacs are barely recognizable
• heart is observed to contain a small tissue clump at E9.5
• at E9.5, hearts show reduced endocardial tissue and abnormal chamber formation and lack of myocardial trabeculation
• at E8.5, heart tube has not initiated looping
• at E8.5, the endocardium is barely recognizable
• at E9.5, the amount of endocardial tissue is reduced
• at E8.5 and E9.5, mutant embryos display a very small heart
• at E9.5, mutant embryos show abnormal ventricular chamber formation
• embryos have poor blood circulation; hearts beat, but few blood cells are observed in heart and vessels
• hearts contract irregularly at E9.5
• observed in capital and caudal regions of embryo at E9.5

nervous system
• at E9.5 embryos display open head folds

craniofacial
• at E9.5, only first branchial arch is observed in mutants, not three

muscle
• at E9.5, mutant hearts show a lack of myocardial trabeculation





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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory