Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Urostm3Rjde mutation
(0 available);
any
Uros mutation
(18 available)
|
|
|
homeostasis/metabolism
hematopoietic system
N |
• 16-18-month old animals show similar ertythrocyte counts, hematocrits, hemoglobin concentrations, mean corpuscular volumes, and total leukocyte counts to wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Urostm3Rjde mutation
(0 available);
any
Uros mutation
(18 available)
|
|
|
homeostasis/metabolism
integument
|
• after ALA treatment and exposure to 405 nm light, epidermis shows slight thickening compared to wild-type skin
|
|
• after 5-aminolevulinic acid (ALA) treatment and exposure to 405 nm light, mice show slight thickening of epidermis, but not the dermis
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Urostm2Rjde mutation
(0 available);
any
Uros mutation
(18 available)
Urostm3Rjde mutation
(0 available);
any
Uros mutation
(18 available)
|
|
|
growth/size/body
|
• splenomegaly is variable with mice having spleens of normal size up to 5 times normal size
|
hematopoietic system
N |
• 16-18-month old animals show similar ertythrocyte counts, hematocrits, hemoglobin concentrations, mean corpuscular volumes, and total leukocyte counts to wild-type mice
|
|
• splenomegaly is variable with mice having spleens of normal size up to 5 times normal size
|
|
• variably increased erythropoiesis is detected in the bone marrow
|
|
• phenotype consistent with compensated hemolytic anemia is observed
|
|
• reticulocyte counts are significantly increased (about 4-fold) compared to wild-type
|
|
• increased iron deposits are observed in spleen
|
|
• mice show elevated hemolysis
|
homeostasis/metabolism
immune system
|
• splenomegaly is variable with mice having spleens of normal size up to 5 times normal size
|
|
• increased iron deposits are observed in spleen
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Urostm1Rjde mutation
(0 available);
any
Uros mutation
(18 available)
Urostm3Rjde mutation
(0 available);
any
Uros mutation
(18 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Urostm3Rjde mutation
(0 available);
any
Uros mutation
(18 available)
Urostm4Rjde mutation
(0 available);
any
Uros mutation
(18 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Urostm2Rjde mutation
(0 available);
any
Uros mutation
(18 available)
Urostm3Rjde mutation
(0 available);
any
Uros mutation
(18 available)
|
|
|
homeostasis/metabolism
integument
|
• separation of epidermal roof from dermal floor is observed
• rare flattened basal keratinocytes are observed
|
|
• ectatic capillaries are observed in superficial dermis, beneath the bullae
|
|
• after ALA treatment and exposure to 405 nm light, thickened dermis shows a minimal mononuclear infiltrate extending to the panniculus carnosus
|
|
• after ALA treatment and exposure to 405 nm light, epidermis and adnexa show considerable acanthosis with a focally compact horn
|
|
• upon loading with 5-aminolevulinic acid (ALA) to accelerate porphyrin accumulation and exposure to 405 nm light for 10 days,, mice show significant porphyrin photosensitivity compared to wild-type mice
|
|
• upon 5-aminolevulinic acid (ALA) treatment and exposure to 405 nm light, bifold skin thickness increases 2-fold compared to wild-type mice
|