About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itih4tm1Mish
targeted mutation 1, Lopa Mishra
MGI:3775819
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itih4tm1Mish/Itih4tm1Mish involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss MGI:3783629
cx2
Itih4tm1Mish/Itih4tm1Mish
Sptbn1tm1Mish/Sptbn1+
involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss MGI:3783628


Genotype
MGI:3783629
hm1
Allelic
Composition
Itih4tm1Mish/Itih4tm1Mish
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itih4tm1Mish mutation (0 available); any Itih4 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice appear normal and are fertile




Genotype
MGI:3783628
cx2
Allelic
Composition
Itih4tm1Mish/Itih4tm1Mish
Sptbn1tm1Mish/Sptbn1+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itih4tm1Mish mutation (0 available); any Itih4 mutation (60 available)
Sptbn1tm1Mish mutation (0 available); any Sptbn1 mutation (139 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• only 1 mouse in 25 developed a liver neoplasm compared to the 40% incidence rate observed in mice carrying just one null allele for Spnb2
• the lone tumor was about 10-fold smaller than the mean tumor sizes observed in the control mice

liver/biliary system
• apoptosis rates are lower in hepatocytes compared to control mice
• hepatocyte proliferation is lower than in controls
• only 1 mouse in 25 developed a liver neoplasm compared to the 40% incidence rate observed in mice carrying just one null allele for Spnb2
• the lone tumor was about 10-fold smaller than the mean tumor sizes observed in the control mice

cellular
• apoptosis rates are lower in hepatocytes compared to control mice
• hepatocyte proliferation is lower than in controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory