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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
RictorGt(RRR347)Byg
gene trap RRR347, BayGenomics
MGI:3775093
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
RictorGt(RRR347)Byg/RictorGt(RRR347)Byg involves: 129P2/OlaHsd MGI:3802635
hm2
RictorGt(RRR347)Byg/RictorGt(RRR347)Byg involves: 129P2/OlaHsd * C57BL/6J MGI:3777012
cx3
Ptentm1Rps/Pten+
RictorGt(RRR347)Byg/Rictor+
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6 MGI:4848133


Genotype
MGI:3802635
hm1
Allelic
Composition
RictorGt(RRR347)Byg/RictorGt(RRR347)Byg
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RictorGt(RRR347)Byg mutation (0 available); any Rictor mutation (140 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• the interface between the trophoblast giant cell layer and the labyrinth is somewhat disorganized
• thicker than in wild-type mice

growth/size/body




Genotype
MGI:3777012
hm2
Allelic
Composition
RictorGt(RRR347)Byg/RictorGt(RRR347)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RictorGt(RRR347)Byg mutation (0 available); any Rictor mutation (140 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4848133
cx3
Allelic
Composition
Ptentm1Rps/Pten+
RictorGt(RRR347)Byg/Rictor+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rps mutation (1 available); any Pten mutation (81 available)
RictorGt(RRR347)Byg mutation (0 available); any Rictor mutation (140 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double mutants tend to live longer than single heterozygous Pten mice

endocrine/exocrine glands
• prostates exhibit signs of hyperplasia but lesions are less severe than in single heterozygous Pten mice

reproductive system
• prostates exhibit signs of hyperplasia but lesions are less severe than in single heterozygous Pten mice

neoplasm
• mutants are protected from prostate cancer development: only 1 of 10 double mutants developed a tumor compared to 5 of 9 single heterozygous Pten mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory