About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptrh2tm1Eruo
targeted mutation 1, Erkki Ruoslahti
MGI:3775073
Summary 2 genotypes


Genotype
MGI:3776794
hm1
Allelic
Composition		 Ptrh2tm1Eruo/Ptrh2tm1Eruo
Genetic
Background		 C57BL/6-Ptrh2tm1Eruo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptrh2tm1Eruo mutation (1 available); any Ptrh2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:131853 )
• mice are viable and fertile




Genotype
MGI:5634971
cn2
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic
Background		 B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Ptrh2tm1.1Eruo mutation (0 available); any Ptrh2 mutation (35 available)
Ptrh2tm1Eruo mutation (1 available); any Ptrh2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
cachexia ( J:220518 )
postnatal growth retardation ( J:220518 )
• progressive age related relative decrease in length and weight

nervous system
decreased brain weight ( J:220518 )
• slightly but significantly decreased at P7
abnormal cerebral cortex morphology ( J:220518 )
• neuron soma size is reduced in the cerebral cortex
cerebellum atrophy ( J:220518 )
• cerebellar atrophy at P7

endocrine/exocrine glands
abnormal pancreatic acinar cell morphology ( J:220518 )
• reduced cross section areas of the pancreatic acini at P7
exocrine pancreatic insufficiency ( J:220518 )
• at P7 as indicated by reduced pancreas elastase levels in the stool and reduced cross section areas of the pancreatic acini

behavior/neurological
ataxia ( J:220518 )
• severe at P7

muscle
abnormal muscle fiber morphology ( J:220518 )
• decreased myocyte soma size

liver/biliary system
abnormal hepatocyte morphology ( J:220518 )
• decreased soma size

digestive/alimentary system
abnormal pancreatic acinar cell morphology ( J:220518 )
• reduced cross section areas of the pancreatic acini at P7
exocrine pancreatic insufficiency ( J:220518 )
• at P7 as indicated by reduced pancreas elastase levels in the stool and reduced cross section areas of the pancreatic acini




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory