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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Notch1tm2.1Pst
targeted mutation 2.1, Pamela Stanley
MGI:3774554
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Notch1tm2Pst/Notch1tm2.1Pst B6.Cg-Notch1tm2.1Pst MGI:3775287
ht2
 		Notch1tm2Pst/Notch1tm2.1Pst involves: 129/Sv * C57BL/6 * SJL MGI:3775288


Genotype
MGI:3775287
ht1
Allelic
Composition		 Notch1tm2Pst/Notch1tm2.1Pst
Genetic
Background		 B6.Cg-Notch1tm2.1Pst
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm2.1Pst mutation (0 available); any Notch1 mutation (115 available)
Notch1tm2Pst mutation (0 available); any Notch1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth retardation ( J:131563 )
• at E9.5, mice exhibit 13 to 17 somites compared to 23 to 26 in Notch1tm2Pst homozygotes

growth/size/body
embryonic growth retardation ( J:131563 )
• at E9.5, mice exhibit 13 to 17 somites compared to 23 to 26 in Notch1tm2Pst homozygotes




Genotype
MGI:3775288
ht2
Allelic
Composition		 Notch1tm2Pst/Notch1tm2.1Pst
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm2.1Pst mutation (0 available); any Notch1 mutation (115 available)
Notch1tm2Pst mutation (0 available); any Notch1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth retardation ( J:131563 )
• at E9.5, mice exhibit 17 to 21 somites compared to 23 to 26 in Notch1tm2Pst homozygotes and 13 to 17 in Notch1tm2.1Pst homozygotes

cardiovascular system
abnormal vasculogenesis ( J:131563 )
• at E10.5 mice are anemic due to defects in vasculogenesis
abnormal heart development ( J:131563 )
• at E10.5, mice exhibit an underdeveloped heart loop

nervous system

hematopoietic system
anemia ( J:131563 )
• at E10.5 mice are anemic due to defects in vasculogenesis

growth/size/body
embryonic growth retardation ( J:131563 )
• at E9.5, mice exhibit 17 to 21 somites compared to 23 to 26 in Notch1tm2Pst homozygotes and 13 to 17 in Notch1tm2.1Pst homozygotes
decreased embryo size ( J:131563 )
• at E10.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory