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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sh2d1atm2Vei
targeted mutation 2, Andre Veillette
MGI:3774546
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Sh2d1atm2Vei/Sh2d1atm2Vei
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6 MGI:3775442
cn2
Sh2d1atm2Vei/Sh2d1atm2Vei
Tg(Lck-cre)1Cwi/0
involves: C57BL/6 MGI:3775441
cn3
Sh2d1atm2Vei/Sh2d1atm2Vei
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 MGI:3775439


Genotype
MGI:3775442
cn1
Allelic
Composition
Sh2d1atm2Vei/Sh2d1atm2Vei
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (9 available); any Cd19 mutation (29 available)
Sh2d1atm2Vei mutation (0 available); any Sh2d1a mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• unlike other conditional knockouts of Apcs, mice exhibit normal numbers of NK T cells, normal antibody response and normal germinal center B cell numbers




Genotype
MGI:3775441
cn2
Allelic
Composition
Sh2d1atm2Vei/Sh2d1atm2Vei
Tg(Lck-cre)1Cwi/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm2Vei mutation (0 available); any Sh2d1a mutation (8 available)
Tg(Lck-cre)1Cwi mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the number of NK T cells is decreased 90% compared to in wild-type mice
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response

hematopoietic system
• the number of NK T cells is decreased 90% compared to in wild-type mice
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response
• in most mice following immunization with TNP-CGG
• however, some mice could mount a partial antibody response




Genotype
MGI:3775439
cn3
Allelic
Composition
Sh2d1atm2Vei/Sh2d1atm2Vei
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm2Vei mutation (0 available); any Sh2d1a mutation (8 available)
Tg(Cd4-cre)1Cwi mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the number of NK T cells is decreased 30% to 50% compared to in wild-type mice
• following immunization with TNP-CGG
• following immunization with TNP-CGG
• following immunization with TNP-CGG
• following immunization with TNP-CGG
• following immunization with TNP-CGG
• following immunization with TNP-CGG

hematopoietic system
• the number of NK T cells is decreased 30% to 50% compared to in wild-type mice
• following immunization with TNP-CGG
• following immunization with TNP-CGG
• following immunization with TNP-CGG
• following immunization with TNP-CGG
• following immunization with TNP-CGG
• following immunization with TNP-CGG





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory