Mouse Genome Informatics
hm1
    Ankrd26Gt(XK525)Byg/Ankrd26Gt(XK525)Byg
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Ankrd26Gt(XK525)Byg/Ankrd26Gt(XK525)Byg mice (right) are extremely large and obese

growth/size/body
• both female and male mutant mice gained 1 or 2 g a week up through 4 months of age
• adult homozygous mice became extremely large and obese

adipose tissue

renal/urinary system

cardiovascular system

homeostasis/metabolism
• elevated in 8- to 10-month-old mice
• elevated in 8- to 10-month-old mice
• total and resting energy expenditure was significantly higher in mutant mice
• when the data was normalized to lean mass, mutant female are still hypermetabolic
• when the data was normalized to lean mass, the mutant male and wild-type had a similar metabolic rate
• confirmed by an insulin tolerance test

behavior/neurological

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:130984