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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ankrd26Gt(XK525)Byg
gene trap XK525, BayGenomics
MGI:3774418
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ankrd26Gt(XK525)Byg/Ankrd26Gt(XK525)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3799316


Genotype
MGI:3799316
hm1
Allelic
Composition
Ankrd26Gt(XK525)Byg/Ankrd26Gt(XK525)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd26Gt(XK525)Byg mutation (0 available); any Ankrd26 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ankrd26Gt(XK525)Byg/Ankrd26Gt(XK525)Byg mice (right) are extremely large and obese

growth/size/body
• both female and male mutant mice gained 1 or 2 g a week up through 4 months of age
• adult homozygous mice became extremely large and obese

adipose tissue

renal/urinary system

cardiovascular system

homeostasis/metabolism
• elevated in 8- to 10-month-old mice
• elevated in 8- to 10-month-old mice
• total and resting energy expenditure was significantly higher in mutant mice
• when the data was normalized to lean mass, mutant female are still hypermetabolic
• when the data was normalized to lean mass, the mutant male and wild-type had a similar metabolic rate
• confirmed by an insulin tolerance test

behavior/neurological

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:130984





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory