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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnk9tm1.1Daba
targeted mutation 1.1, Douglas A Bayliss
MGI:3774332
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcnk9tm1.1Daba/Kcnk9tm1.1Daba involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3806600
cx2
 		Kcnk3tm1.1Daba/Kcnk3tm1.1Daba
Kcnk9tm1.1Daba/Kcnk9tm1.1Daba 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3806597
cx3
 		Kcnk3tm1.1Daba/Kcnk3tm1.1Daba
Kcnk9tm1.1Daba/Kcnk9tm1.1Daba 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3796531


Genotype
MGI:3806600
hm1
Allelic
Composition		 Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk9tm1.1Daba mutation (0 available); any Kcnk9 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:130850 )
N
• no abnormalities were found in the pH sensitivity of neurons in the retrotrapezoid nucleus
abnormal action potential ( J:130850 )
• serotonergic neurons within the raphe nucleus lack pH dependent-changes in discharge
• wild-type firing rates decrease from 1.2 Hz to 0.5 Hz over a pH range of 6.9 to pH 7.5 while the firing rate of mutant neurons remains constant at about 0.5 Hz over the same pH range
• there are no changes in the averaged I-V relationships obtained during extracellular acidification to alkalization while wild-type neurons rectify weakly and reverse near the expected Ek

respiratory system
respiratory system phenotype ( J:130850 )
N
• whole animal ventilatory response to carbon dioxide is completely retained in this mice




Genotype
MGI:3806597
cx2
Allelic
Composition		 Kcnk3tm1.1Daba/Kcnk3tm1.1Daba
Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk3tm1.1Daba mutation (0 available); any Kcnk3 mutation (34 available)
Kcnk9tm1.1Daba mutation (0 available); any Kcnk9 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:130850 )
N
• no abnormalities were found in the pH sensitivity of neurons in the retrotrapezoid nucleus
abnormal action potential ( J:130850 )
• serotonergic neurons within the raphe nucleus lack pH dependent-changes in discharge
• wild-type firing rates decrease from 1.2 Hz to 0.5 Hz over a pH range of 6.9 to pH 7.5 while the firing rate of mutant neurons remains constant at about 0.5 Hz over the same pH range
• there are no changes in the averaged I-V relationships obtained during extracellular acidification to alkalization while wild-type neurons rectify weakly and reverse near the expected Ek

respiratory system
respiratory system phenotype ( J:130850 )
N
• whole animal ventilatory response to carbon dioxide is completely retained in this mice




Genotype
MGI:3796531
cx3
Allelic
Composition		 Kcnk3tm1.1Daba/Kcnk3tm1.1Daba
Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk3tm1.1Daba mutation (0 available); any Kcnk3 mutation (34 available)
Kcnk9tm1.1Daba mutation (0 available); any Kcnk9 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating aldosterone level ( J:131927 )
• males display primary hyperaldosteronism
• mutants fail to suppress aldosterone production in response to dietary sodium loading
• candesartan, an AT1R receptor blocker, does not normalize aldosterone production to control levels in mutants
hypokalemia ( J:131927 )
• mutants are mildly hypokalemic across all diets, with plasma potassium on the nonsalt diet reduced by about 25%

endocrine/exocrine glands
abnormal adrenal gland physiology ( J:131927 )
• adrenal zona glomerulosa cells display altered electrophysiological properties; the pH- and anesthetic-sensitive background currents are absent
• membrane potential is significantly more depolarized in mutant adrenal zona glomerulosa cells than in controls
• however, cellular morphology and zonation within the adrenal gland are normal in males

cardiovascular system

nervous system
abnormal channel response ( J:131927 )
• adrenal zona glomerulosa cells display altered electrophysiological properties; the pH- and anesthetic-sensitive background currents are absent
• membrane potential is significantly more depolarized in mutant adrenal zona glomerulosa cells than in controls

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
primary hyperaldosteronism DOID:446 OMIM:605635
OMIM:613677
 J:131927




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory