Analysis Tools
normal phenotype
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• mice are viable and fertile
• mice have normal expression of CD4 in developing and mature T cells
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Allele Symbol Allele Name Allele ID |
Rr96tm1Yzo targeted mutation 1, Yong-Rui Zou MGI:3774141 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable and fertile
• mice have normal expression of CD4 in developing and mature T cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 43% of CD8+ T cells co-express CD4
• this percentage is similar to the 46% of CD8+ T cells that have excised the floxed CD4 silencer element as based on southern analysis
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• 43% of CD8+ T cells co-express CD4
• this percentage is similar to the 46% of CD8+ T cells that have excised the floxed CD4 silencer element as based on southern analysis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD4 silencing is defective in these mice leading to expression of CD4 on cytotoxic T cells that normally only express CD8
• these peripheral double positive T cells have the cytotoxic effector functions of CD8+ T cells
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• all peripheral CD8+ T cells co-express CD4 leading to a large increase in double positive numbers in the spleen
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• CD4 silencing is defective in these mice leading to expression of CD4 on cytotoxic T cells that normally only express CD8
• these peripheral double positive T cells have the cytotoxic effector functions of CD8+ T cells
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• all peripheral CD8+ T cells co-express CD4 leading to a large increase in double positive numbers in the spleen
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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