Analysis Tools
embryo
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• dramatically reduced at E15.5, most notable in central junctional zone of placenta
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• at E12.5, volume of junctional zone is reduced by about 50% while at 15.5 volume is reduced by 30%
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• dramatic reduction in spongiotrophoblast cells at E15.5, particularly in central junctional zone of placenta
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• dramatic reduction in glycogen cells is seen at E15.5 in junctional zone
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• volume of labyrinthine zone at E12.5 is reduced by about 50% compared to wild-type, and at 15.5, volume is reduced by 30%
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• at E12.5, weight is lower than wild-type
• at E12.5, 15.5, and 18.5, fetal:placental ratio (weights ratio) significantly higher than for wild-type
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• at E12.5, placental have pale brown/bluish coloration in contrast to red/pink color of wild-type placentas
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growth/size/body
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• at birth, weights are significantly lower than littermates
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• at E15.5, fetal weight and crown-rump length begin to lag behind wild-type, which continues through parturition
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• at E15.5, fetal weight and crown-rump length begin to lag behind wild-type, which continues through parturition
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