Phenotypes associated with this allele

• Allele Symbol: Ier3^tm1Raku
• Allele Name: targeted mutation 1, Rajiv Kumar
• Allele ID: MGI:3773690
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ier3^tm1Raku/Ier3^tm1Raku	involves: 129S6/SvEvTac	MGI:3783743

Genotype
MGI:3783743

hm1

• Allelic Composition: Ier3^tm1Raku/Ier3^tm1Raku
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:131099 )

• significantly greater myofibril diameter in cardiomyocyte

heart left ventricle hypertrophy ( J:131099 )

• an increase in left ventricular diameter and mass

decreased cardiac muscle contractility ( J:131099 )

• fractional shortening and left ventricular ejection fraction were reduced

increased heart rate ( J:131099 )

increased systemic arterial blood pressure ( J:131099 )

• 8 weeks old homozygous mice had elevations of systemic arterial pressure

muscle

increased myocardial fiber size ( J:131099 )

• significantly greater myofibril diameter in cardiomyocyte

heart left ventricle hypertrophy ( J:131099 )

• an increase in left ventricular diameter and mass

decreased cardiac muscle contractility ( J:131099 )

• fractional shortening and left ventricular ejection fraction were reduced

growth/size/body

heart left ventricle hypertrophy ( J:131099 )

• an increase in left ventricular diameter and mass