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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tead2tm1Hssk
targeted mutation 1, Hiroshi Sasaki
MGI:3773644
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tead2tm1Hssk/Tead2tm1Hssk either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1) MGI:3797236
cx2
Tead1tm1Hssk/Tead1+
Tead2tm1Hssk/Tead2tm1Hssk
Yap1tm1Smil/Yap1+
either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1) MGI:3797240
cx3
Tead1tm1Hssk/Tead1tm1Hssk
Tead2tm1Hssk/Tead2+
Yap1tm1Smil/Yap1+
either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1) MGI:3797243
cx4
Tead1tm1Hssk/Tead1tm1Hssk
Tead2tm1Hssk/Tead2tm1Hssk
either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1) MGI:3797237
cx5
Tead1tm1Hssk/Tead1+
Tead2tm1Hssk/Tead2tm1Hssk
either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1) MGI:3797238
cx6
Tead1tm1Hssk/Tead1tm1Hssk
Tead2tm1Hssk/Tead2+
either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1) MGI:3797239
cx7
Sox11tm2.2Weg/Sox11+
Sox4tm1.1Vlf/Sox4+
Tead2tm1Hssk/Tead2tm1Hssk
involves: 129 * C57BL/6 * CBA * FVB/N MGI:5285372


Genotype
MGI:3797236
hm1
Allelic
Composition
Tead2tm1Hssk/Tead2tm1Hssk
Genetic
Background
either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice exhibit no overt abnormalities and are fertile




Genotype
MGI:3797240
cx2
Allelic
Composition
Tead1tm1Hssk/Tead1+
Tead2tm1Hssk/Tead2tm1Hssk
Yap1tm1Smil/Yap1+
Genetic
Background
either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1tm1Hssk mutation (1 available); any Tead1 mutation (227 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (20 available)
Yap1tm1Smil mutation (0 available); any Yap1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• mutants exhibit smaller posterior tissues
• defective embryonic turning




Genotype
MGI:3797243
cx3
Allelic
Composition
Tead1tm1Hssk/Tead1tm1Hssk
Tead2tm1Hssk/Tead2+
Yap1tm1Smil/Yap1+
Genetic
Background
either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1tm1Hssk mutation (1 available); any Tead1 mutation (227 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (20 available)
Yap1tm1Smil mutation (0 available); any Yap1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• mutants show essentially the same morphological defects as double Tead1 and Tead2 homozygotes
• embryos develop a posterior-ventral protrusion
• embryos develop a bulbous allantois




Genotype
MGI:3797237
cx4
Allelic
Composition
Tead1tm1Hssk/Tead1tm1Hssk
Tead2tm1Hssk/Tead2tm1Hssk
Genetic
Background
either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1tm1Hssk mutation (1 available); any Tead1 mutation (227 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• embryos are slightly smaller at E7.5 and small at E8.5

embryo
• cell apoptosis is increased in E7.75 embryos
• mutants fail to undergo embryonic turning at E8.75
• embryos are slightly smaller at E7.5 and small at E8.5
• an abnormal protrusion to the ventral side develops at the posterior end of the mutant embryo at E8.75, with abnormal cell accumulation in this region
• marker analysis indicates that development of the posterior definitive endoderm is partially compromised
• lateral plate mesoderm is displaced toward the lateral margins
• paraxial mesoderm is displaced toward the lateral margins
• the neural plate remains flat and the boundary between the neuroectoderm and the underlying mesoderm is not clearly demarcated
• neural plate is kinked dorso-ventrally at E8.75
• in the central region, the neural plate has not fused along the dorsal ridges to form a neural tube at E8.5
• marker analysis indicates defects in notochordal development
• E8.5 embryos lack a notochord
• no morphologically identifiable somites form
• embryos are highly disorganized at E9.5, and typically develop a posterior-ventral protrusion
• in the yolk sac, specification of both endothelia and erythroblasts occurs, but their development into an organized primitive vascular plexus is defective
• E9.5 embryos develop a bulbous allantois
• E9.5 embryos develop a bulbous allantois that fails to fuse with the chorion

cardiovascular system
• in the yolk sac, specification of both endothelia and erythroblasts occurs, but their development into an organized primitive vascular plexus is defective
• the anterior region is dorsally folded and there are two heart tubes at E8.5, indicating that the two heart primordia failed to fuse

cellular
• cell apoptosis is increased in E7.75 embryos
• cell proliferation is reduced in E7.75 embryos

nervous system
• the neural plate remains flat and the boundary between the neuroectoderm and the underlying mesoderm is not clearly demarcated
• neural plate is kinked dorso-ventrally at E8.75
• in the central region, the neural plate has not fused along the dorsal ridges to form a neural tube at E8.5




Genotype
MGI:3797238
cx5
Allelic
Composition
Tead1tm1Hssk/Tead1+
Tead2tm1Hssk/Tead2tm1Hssk
Genetic
Background
either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1tm1Hssk mutation (1 available); any Tead1 mutation (227 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5
• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5

embryo
• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5




Genotype
MGI:3797239
cx6
Allelic
Composition
Tead1tm1Hssk/Tead1tm1Hssk
Tead2tm1Hssk/Tead2+
Genetic
Background
either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1tm1Hssk mutation (1 available); any Tead1 mutation (227 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• mutants are developmentally delayed but resemble normal E8.5 embryos

growth/size/body
• mutants are developmentally delayed but resemble normal E8.5 embryos




Genotype
MGI:5285372
cx7
Allelic
Composition
Sox11tm2.2Weg/Sox11+
Sox4tm1.1Vlf/Sox4+
Tead2tm1Hssk/Tead2tm1Hssk
Genetic
Background
involves: 129 * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.2Weg mutation (0 available); any Sox11 mutation (1 available)
Sox4tm1.1Vlf mutation (0 available); any Sox4 mutation (3 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• higher incident than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes
• higher incident than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes

embryo
• at E11.5, mice exhibit cell death around the notochord in the lumbar, but not thoracic, region compared with wild-type mice

skeleton
• more severe and more frequent than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes





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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory