All Phenotypes Tead1<tm1Hssk> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tead1^tm1Hssk/Tead1^tm1Hssk	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)	MGI:3797234
cx2	Tead1^tm1Hssk/Tead1⁺ Tead2^tm1Hssk/Tead2^tm1Hssk Yap1^tm1Smil/Yap1⁺	either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)	MGI:3797240
cx3	Tead1^tm1Hssk/Tead1^tm1Hssk Tead2^tm1Hssk/Tead2⁺ Yap1^tm1Smil/Yap1⁺	either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)	MGI:3797243
cx4	Tead1^tm1Hssk/Tead1^tm1Hssk Tead2^tm1Hssk/Tead2⁺	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)	MGI:3797239
cx5	Tead1^tm1Hssk/Tead1^tm1Hssk Tead2^tm1Hssk/Tead2^tm1Hssk	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)	MGI:3797237
cx6	Tead1^tm1Hssk/Tead1⁺ Tead2^tm1Hssk/Tead2^tm1Hssk	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)	MGI:3797238

Allelic Composition	Tead1^tm1Hssk/Tead1^tm1Hssk
Genetic Background	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1^tm1Hssk mutation (1 available); any Tead1 mutation (274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:131426 )

• most die around E11.5, although some die even earlier

cardiovascular system

abnormal myocardial trabeculae morphology ( J:131426 )

• reduction of myocardium trabeculation

muscle

abnormal myocardial trabeculae morphology ( J:131426 )

• reduction of myocardium trabeculation

Allelic Composition	Tead1^tm1Hssk/Tead1⁺ Tead2^tm1Hssk/Tead2^tm1Hssk Yap1^tm1Smil/Yap1⁺
Genetic Background	either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1^tm1Hssk mutation (1 available); any Tead1 mutation (274 available)
Tead2^tm1Hssk mutation (1 available); any Tead2 mutation (31 available)
Yap1^tm1Smil mutation (0 available); any Yap1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal developmental patterning ( J:131426 )

• mutants exhibit smaller posterior tissues

abnormal embryo turning ( J:131426 )

• defective embryonic turning

Allelic Composition	Tead1^tm1Hssk/Tead1^tm1Hssk Tead2^tm1Hssk/Tead2⁺ Yap1^tm1Smil/Yap1⁺
Genetic Background	either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:131426 )

• mutants show essentially the same morphological defects as double Tead1 and Tead2 homozygotes

abnormal embryonic tissue morphology ( J:131426 )

• embryos develop a posterior-ventral protrusion

abnormal allantois morphology ( J:131426 )

• embryos develop a bulbous allantois

Allelic Composition	Tead1^tm1Hssk/Tead1^tm1Hssk Tead2^tm1Hssk/Tead2⁺
Genetic Background	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryonic growth retardation ( J:131426 )

• mutants are developmentally delayed but resemble normal E8.5 embryos

growth/size/body

embryonic growth retardation ( J:131426 )

• mutants are developmentally delayed but resemble normal E8.5 embryos

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:131426 )

• die at E9.5

growth/size/body

decreased embryo size ( J:131426 )

• embryos are slightly smaller at E7.5 and small at E8.5

embryo

increased embryonic tissue cell apoptosis ( J:131426 )

• cell apoptosis is increased in E7.75 embryos

abnormal developmental patterning ( J:131426 )

failure of initiation of embryo turning ( J:131426 )

• mutants fail to undergo embryonic turning at E8.75

decreased embryo size ( J:131426 )

• embryos are slightly smaller at E7.5 and small at E8.5

abnormal embryonic tissue morphology ( J:131426 )

• an abnormal protrusion to the ventral side develops at the posterior end of the mutant embryo at E8.75, with abnormal cell accumulation in this region

abnormal posterior definitive endoderm morphology ( J:131426 )

• marker analysis indicates that development of the posterior definitive endoderm is partially compromised

abnormal lateral plate mesoderm morphology ( J:131426 )

• lateral plate mesoderm is displaced toward the lateral margins

abnormal paraxial mesoderm morphology ( J:131426 )

• paraxial mesoderm is displaced toward the lateral margins

abnormal neural plate morphology ( J:131426 )

• the neural plate remains flat and the boundary between the neuroectoderm and the underlying mesoderm is not clearly demarcated

• neural plate is kinked dorso-ventrally at E8.75

open neural tube ( J:131426 )

• in the central region, the neural plate has not fused along the dorsal ridges to form a neural tube at E8.5

abnormal notochord morphology ( J:131426 )

• marker analysis indicates defects in notochordal development

absent notochord ( J:131426 )

• E8.5 embryos lack a notochord

absent somites ( J:131426 )

• no morphologically identifiable somites form

disorganized embryonic tissue ( J:131426 )

• embryos are highly disorganized at E9.5, and typically develop a posterior-ventral protrusion

abnormal extraembryonic tissue morphology ( J:131426 )

abnormal vitelline vasculature morphology ( J:131426 )

• in the yolk sac, specification of both endothelia and erythroblasts occurs, but their development into an organized primitive vascular plexus is defective

abnormal allantois morphology ( J:131426 )

• E9.5 embryos develop a bulbous allantois

failure of chorioallantoic fusion ( J:131426 )

• E9.5 embryos develop a bulbous allantois that fails to fuse with the chorion

cardiovascular system

abnormal vitelline vasculature morphology ( J:131426 )

• in the yolk sac, specification of both endothelia and erythroblasts occurs, but their development into an organized primitive vascular plexus is defective

abnormal heart tube morphology ( J:131426 )

• the anterior region is dorsally folded and there are two heart tubes at E8.5, indicating that the two heart primordia failed to fuse

cellular

increased embryonic tissue cell apoptosis ( J:131426 )

• cell apoptosis is increased in E7.75 embryos

decreased cell proliferation ( J:131426 )

• cell proliferation is reduced in E7.75 embryos

nervous system

abnormal neural plate morphology ( J:131426 )

• the neural plate remains flat and the boundary between the neuroectoderm and the underlying mesoderm is not clearly demarcated

• neural plate is kinked dorso-ventrally at E8.75

open neural tube ( J:131426 )

• in the central region, the neural plate has not fused along the dorsal ridges to form a neural tube at E8.5

Allelic Composition	Tead1^tm1Hssk/Tead1⁺ Tead2^tm1Hssk/Tead2^tm1Hssk
Genetic Background	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

incomplete rostral neuropore closure ( J:131426 )

• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5

exencephaly ( J:131426 )

• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5

embryo

incomplete rostral neuropore closure ( J:131426 )

• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5

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