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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Traf6tm2Ywc
targeted mutation 2, Yongwon Choi
MGI:3773273
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cd28tm1Mak/Cd28tm1Mak
Tg(Cd4-cre)1Cwi/?
Traf6tm2Ywc/Traf6tm2Ywc
involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:3773280
cn2
Traf6tm2Ywc/Traf6tm2Ywc
Tg(Cd4-cre)1Cwi/?
involves: C57BL/6 * DBA/2 MGI:3773278
cn3
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
Traf6tm2Ywc/Traf6tm2Ywc
involves: C57BL/6 * DBA/2 MGI:3773279


Genotype
MGI:3773280
cn1
Allelic
Composition
Cd28tm1Mak/Cd28tm1Mak
Tg(Cd4-cre)1Cwi/?
Traf6tm2Ywc/Traf6tm2Ywc
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Mak mutation (12 available); any Cd28 mutation (53 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Traf6tm2Ywc mutation (0 available); any Traf6 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD4 T cells proliferate in vitro at normal levels when stimulated with anti-CD3 antibody compared
• increased number of CD44highCD62low T cells in the spleen and lymph nodes
• increased number of CD69+ T cells are found in the spleen and lymph nodes
• CD4 T cells secrete IL-2 upon stimulation with anti -CD3 or -CD3/-CD28 antibodies

hematopoietic system
• CD4 T cells proliferate in vitro at normal levels when stimulated with anti-CD3 antibody compared
• increased number of CD44highCD62low T cells in the spleen and lymph nodes
• increased number of CD69+ T cells are found in the spleen and lymph nodes

cellular
• CD4 T cells proliferate in vitro at normal levels when stimulated with anti-CD3 antibody compared




Genotype
MGI:3773278
cn2
Allelic
Composition
Traf6tm2Ywc/Traf6tm2Ywc
Tg(Cd4-cre)1Cwi/?
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (10 available)
Traf6tm2Ywc mutation (0 available); any Traf6 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased number of CD44highCD62low T cells are found in the spleen and lymph nodes
• increased number of CD69+ T cells are found in the spleen and lymph nodes
• CD4 T cells are resistant to anergy induced in vitro as measured by cellular proliferation in response to anti-CD3 restimulation
• proliferation rates are 5-10 fold higher upon restimulation compared to wild-type controls
• CD4 T cells expressing the Vbeta8 chain continue to proliferate upon restimulation with the superantigen SEB compared to CD4 T cells from control mice that are tolerized and do not proliferate in response to restimulation

hematopoietic system
• increased number of CD44highCD62low T cells are found in the spleen and lymph nodes
• increased number of CD69+ T cells are found in the spleen and lymph nodes




Genotype
MGI:3773279
cn3
Allelic
Composition
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
Traf6tm2Ywc/Traf6tm2Ywc
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
Traf6tm2Ywc mutation (0 available); any Traf6 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD4 T cells from mice immunized with OVA antigen secrete almost 10-fold more IL-2 upon in vitro antigen restimulate compared to mice transgenic only for the T cell receptor
• OVA antigen specific T cells continue to proliferate upon antigen restimulation in a transfer model of tolerance





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory