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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lhx2tm1Monu
targeted mutation 1, Edwin S Monuki
MGI:3772179
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Lhx2tm1Monu/Lhx2tm1Monu 		involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:3772184
cn2
 		Emx1tm1(cre)Yql/Emx1+
Lhx2tm1Monu/Lhx2tm1Monu 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:3772185
cn3
 		Lhx2tm1Monu/Lhx2tm1Monu
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA MGI:4453348
cn4
 		Lhx2tm1Monu/Lhx2tm1Dra
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA MGI:4453346
cn5
 		Lhx2tm1Monu/Lhx2tm1Monu
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129P2/OlaHsd * CD-1 * FVB/N MGI:3772183


Genotype
MGI:3772184
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Lhx2tm1Monu/Lhx2tm1Monu
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Lhx2tm1Monu mutation (0 available); any Lhx2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal telencephalon development ( J:130167 )
• at E12.5, following tamoxifen treatment at E8.5, mice display an expansion of the cortical hem and a reduction in dorsal telencephalon
abnormal cerebral cortex morphology ( J:130167 )
• at E12.5, following tamoxifen treatment at E8.5, mice display an expansion of the cortical hem and a reduction in dorsal telencephalon
• treatment with tamoxifen at E10.5 results in subtle to inapparent abnormalities in the cortical hem at E12.5




Genotype
MGI:3772185
cn2
Allelic
Composition		 Emx1tm1(cre)Yql/Emx1+
Lhx2tm1Monu/Lhx2tm1Monu
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)
Lhx2tm1Monu mutation (0 available); any Lhx2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex morphology ( J:130167 )
• mice exhibit subtle to inapparent abnormalities in the cortical hem at E12.5




Genotype
MGI:4453348
cn3
Allelic
Composition		 Lhx2tm1Monu/Lhx2tm1Monu
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1Monu mutation (0 available); any Lhx2 mutation (12 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal hair growth ( J:159209 )
• most mice shaved and treated with Tamoxifen at 3 weeks of age do not regrow hair
abnormal hair cycle anagen phase ( J:159209 )
• unable to develop beyond Sub-stage III and assemble a normal hair shaft




Genotype
MGI:4453346
cn4
Allelic
Composition		 Lhx2tm1Monu/Lhx2tm1Dra
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1Dra mutation (0 available); any Lhx2 mutation (12 available)
Lhx2tm1Monu mutation (0 available); any Lhx2 mutation (12 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal hair growth ( J:159209 )
• most mice shaved and treated with Tamoxifen at 3 weeks of age do not regrow hair
abnormal hair cycle anagen phase ( J:159209 )
• unable to develop beyond Sub-stage III and assemble a normal hair shaft




Genotype
MGI:3772183
cn5
Allelic
Composition		 Lhx2tm1Monu/Lhx2tm1Monu
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129P2/OlaHsd * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1Monu mutation (0 available); any Lhx2 mutation (12 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal telencephalon development ( J:130167 )
• at E12.5, mice display an expansion of the cortical hem and a reduction in dorsal telencephalon
abnormal cerebral cortex morphology ( J:130167 )
• at E12.5, mice display an expansion of the cortical hem and a reduction in dorsal telencephalon




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory