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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rpe65tm1Lrcb
targeted mutation 1, Christian Grimm
MGI:3771723
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rpe65tm1Lrcb/Rpe65tm1Lrcb 129S6/SvEvTac-Rpe65tm1Lrcb MGI:3771806


Genotype
MGI:3771806
hm1
Allelic
Composition
Rpe65tm1Lrcb/Rpe65tm1Lrcb
Genetic
Background
129S6/SvEvTac-Rpe65tm1Lrcb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpe65tm1Lrcb mutation (0 available); any Rpe65 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• levels of rhodopsin within the outer segments are 6% that of wild-type mice
• is apparent in mice 4 weeks of age
• outer segment layer shortens as mice age with differences visible by 12 weeks of age
• mice show better preservation of the OS compared to Rpe65tm1Tmr homozygotes
• occurs in mice by one year of age
• lipid-like inclusions form in the RPE of mice by 8 weeks of age
• occurs as mice age with the thickness being half that of wild-type mice by one year of age
• light sensitivity in 8 week old mice is reduced by about 2.5 log units as measured by the luminance required to generate a half-maximal b-wave under scotopic conditions
• b-wave amplitude generated by light exposure decreases between 12 and 24 weeks of age
• rhodopsin regeneration in light-bleached retinas is slower and reaches a plateau at about half the maximal level of non-bleached, dark-adapted mice

pigmentation
• lipid-like inclusions form in the RPE of mice by 8 weeks of age

homeostasis/metabolism
• 11-cis-retinal levels are reduced by 94 to 97% in dark adapted retinas as compared to age matched controls
• retinyl esters accumulate in the eye at a rate of 13 pmol/day until the increases stop at 24 weeks of age

nervous system
• levels of rhodopsin within the outer segments are 6% that of wild-type mice
• is apparent in mice 4 weeks of age
• outer segment layer shortens as mice age with differences visible by 12 weeks of age
• mice show better preservation of the OS compared to Rpe65tm1Tmr homozygotes
• occurs in mice by one year of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinitis Pigmentosa 20; RP20 613794 J:130076





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory