• mice exhibit no abnormalities

• following tamoxifen treatment, mice display normal alveolar spaces and normal lung structure with no detectable mucosal cells (J:153715)

• expression of key lung molecular markers remains normal in adult lungs (J:153715)

• following tamoxifen treatment, mice display uterine hyperplasia (J:153715)

• following tamoxifen treatment, mice display dermal papillomas

• following tamoxifen treatment, mice display dermal papillomas

• survival time of double mutants is shorter than either single mutant, with mice dying by 16 weeks of age

• decrease in the number of apoptotic cells in the endothelium epithelium compared to single Pten mutants (J:162027)

• proliferation is increased in the endothelium epithelium (J:162027)

• mutants exhibit endometrial hyperplasia at 2 weeks of age and develop endometrial adenocarcinoma at 4 weeks of age (J:162027)

• however, myometrial hyperplasia is not observed in the uteri of mutants (J:162027)

• increase in uterine weight at 2 weeks of age, with weight at 4 weeks greater than in single Pten mutants (J:162027)

• mutants exhibit distant metastases into the ovary, diaphragmatic skeletal muscle, lymph node, colon and pancreas

• development of endometrial cancer is accelerated compared to either single mutant (J:162027)

• mice exhibit an increase in the ratio of gland to stroma compared to in Errfi1^tm1Jwj homozygotes (J:150007)

• however, the myometrium is not enlarged (J:150007)

• the number of endometrial glands is increased compared to in Errfi1^tm1Jwj homozygotes due to increased proliferation (J:150007)

• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1^tm1Jwj homozygotes (J:150007)

• mice develop endometrial hyperplasia (J:150007)

• after 3 months, ovectamized mice treated with E2 and P4 exhibit increased uterus weight compared to in similarly treated Errfi1^tm1Jwj homozygotes (J:150007)

• at 5 months, uterine wet weight is increased compared to in Errfi1^tm1Jwj homozygotes (J:150007)

• ovectamized mice treated with E2 or E2 and P4 exhibit increased uterus weight compared to in similarly treated Errfi1^tm1Jwj homozygotes (J:150007)

• despite normal oocyte numbers and uterine environment, female mice are infertile (J:150007)

• E2-treated, ovariectomized mice develop endometrial cancer unlike similarly treated Errfi1^tm1Jwj homozygotes (J:150007)

• however, ovariectomized mice treated with E2 and P4 do not develop endometrial cancer (J:150007)

• neoplastic endometrial glands invade adjacent structures such as the colon, pancreas, and skeletal muscle (J:150007)