Mouse Genome Informatics
hm1
    Errfi1tm1Jwj/Errfi1tm1Jwj
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice exhibit no abnormalities


Mouse Genome Informatics
cn2
    Errfi1tm1Jwj/Errfi1tm1Jwj
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+

involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
N
• following tamoxifen treatment, mice display normal alveolar spaces and normal lung structure with no detectable mucosal cells
• expression of key lung molecular markers remains normal in adult lungs

reproductive system
• following tamoxifen treatment, mice display uterine hyperplasia

integument
• following tamoxifen treatment, mice display dermal papillomas

tumorigenesis
• following tamoxifen treatment, mice display dermal papillomas


Mouse Genome Informatics
cn3
    Errfi1tm1Jwj/Errfi1tm1Jwj
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival time of double mutants is shorter than either single mutant, with mice dying by 16 weeks of age

reproductive system
• decrease in the number of apoptotic cells in the endothelium epithelium compared to single Pten mutants
• proliferation is increased in the endothelium epithelium
• mutants exhibit endometrial hyperplasia at 2 weeks of age and develop endometrial adenocarcinoma at 4 weeks of age
• however, myometrial hyperplasia is not observed in the uteri of mutants
• increase in uterine weight at 2 weeks of age, with weight at 4 weeks greater than in single Pten mutants

tumorigenesis
• mutants exhibit distant metastases into the ovary, diaphragmatic skeletal muscle, lymph node, colon and pancreas
• development of endometrial cancer is accelerated compared to either single mutant

Mouse Models of Human Disease
OMIM IDRef(s)
Endometrial Cancer 608089 J:162027


Mouse Genome Informatics
cn4
    Errfi1tm1Jwj/Errfi1tm1Jwj
Pgrtm2(cre)Lyd/Pgr+

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• mice exhibit an increase in the ratio of gland to stroma compared to in Errfi1tm1Jwj homozygotes
• however, the myometrium is not enlarged
• the number of endometrial glands is increased compared to in Errfi1tm1Jwj homozygotes due to increased proliferation
• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1tm1Jwj homozygotes
• mice develop endometrial hyperplasia
• at 5 months, uterine wet weight is increased compared to in Errfi1tm1Jwj homozygotes
• after 3 months, ovectamized mice treated with E2 and P4 exhibit increased uterus weight compared to in similarly treated Errfi1tm1Jwj homozygotes
• despite normal oocyte numbers and uterine environment, female mice are infertile

tumorigenesis
• E2-treated, ovariectomized mice develop endometrial cancer unlike similarly treated Errfi1tm1Jwj homozygotes
• however, ovariectomized mice treated with E2 and P4 do not develop endometrial cancer
• neoplastic endometrial glands invade adjacent structures such as the colon, pancreas, and skeletal muscle

endocrine/exocrine glands
• the number of endometrial glands is increased compared to in Errfi1tm1Jwj homozygotes due to increased proliferation
• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1tm1Jwj homozygotes

Mouse Models of Human Disease
OMIM IDRef(s)
Endometrial Cancer 608089 J:150007