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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Errfi1tm1Jwj
targeted mutation 1, Jae-Wook Jeong
MGI:3769404
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Errfi1tm1Jwj/Errfi1tm1Jwj involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3769413
cn2
Errfi1tm1Jwj/Errfi1tm1Jwj
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4943702
cn3
Errfi1tm1Jwj/Errfi1tm1Jwj
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:4944273
cn4
Errfi1tm1Jwj/Errfi1tm1Jwj
Pgrtm2(cre)Lyd/Pgr+
involves: 129S1/Sv * 129X1/SvJ MGI:3850221


Genotype
MGI:3769413
hm1
Allelic
Composition
Errfi1tm1Jwj/Errfi1tm1Jwj
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Errfi1tm1Jwj mutation (0 available); any Errfi1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice exhibit no abnormalities




Genotype
MGI:4943702
cn2
Allelic
Composition
Errfi1tm1Jwj/Errfi1tm1Jwj
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic
Background
involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Errfi1tm1Jwj mutation (0 available); any Errfi1 mutation (7 available)
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (315 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
N
• following tamoxifen treatment, mice display normal alveolar spaces and normal lung structure with no detectable mucosal cells
• expression of key lung molecular markers remains normal in adult lungs

reproductive system
• following tamoxifen treatment, mice display uterine hyperplasia

integument
• following tamoxifen treatment, mice display dermal papillomas

neoplasm
• following tamoxifen treatment, mice display dermal papillomas




Genotype
MGI:4944273
cn3
Allelic
Composition
Errfi1tm1Jwj/Errfi1tm1Jwj
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Errfi1tm1Jwj mutation (0 available); any Errfi1 mutation (7 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (24 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival time of double mutants is shorter than either single mutant, with mice dying by 16 weeks of age

reproductive system
• development of endometrial cancer is accelerated compared to either single mutant
• decrease in the number of apoptotic cells in the endothelium epithelium compared to single Pten mutants
• proliferation is increased in the endothelium epithelium
• mutants exhibit endometrial hyperplasia at 2 weeks of age and develop endometrial adenocarcinoma at 4 weeks of age
• however, myometrial hyperplasia is not observed in the uteri of mutants
• increase in uterine weight at 2 weeks of age, with weight at 4 weeks greater than in single Pten mutants

neoplasm
• mutants exhibit distant metastases into the ovary, diaphragmatic skeletal muscle, lymph node, colon and pancreas
• development of endometrial cancer is accelerated compared to either single mutant

Mouse Models of Human Disease
OMIM ID Ref(s)
Endometrial Cancer 608089 J:162027




Genotype
MGI:3850221
cn4
Allelic
Composition
Errfi1tm1Jwj/Errfi1tm1Jwj
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Errfi1tm1Jwj mutation (0 available); any Errfi1 mutation (7 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• E2-treated, ovariectomized mice develop endometrial cancer unlike similarly treated Errfi1tm1Jwj homozygotes
• however, ovariectomized mice treated with E2 and P4 do not develop endometrial cancer
• neoplastic endometrial glands invade adjacent structures such as the colon, pancreas, and skeletal muscle
• mice exhibit an increase in the ratio of gland to stroma compared to in Errfi1tm1Jwj homozygotes
• however, the myometrium is not enlarged
• the number of endometrial glands is increased compared to in Errfi1tm1Jwj homozygotes due to increased proliferation
• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1tm1Jwj homozygotes
• mice develop endometrial hyperplasia
• at 5 months, uterine wet weight is increased compared to in Errfi1tm1Jwj homozygotes
• after 3 months, ovectamized mice treated with E2 and P4 exhibit increased uterus weight compared to in similarly treated Errfi1tm1Jwj homozygotes
• despite normal oocyte numbers and uterine environment, female mice are infertile

neoplasm
• E2-treated, ovariectomized mice develop endometrial cancer unlike similarly treated Errfi1tm1Jwj homozygotes
• however, ovariectomized mice treated with E2 and P4 do not develop endometrial cancer
• neoplastic endometrial glands invade adjacent structures such as the colon, pancreas, and skeletal muscle

endocrine/exocrine glands
• the number of endometrial glands is increased compared to in Errfi1tm1Jwj homozygotes due to increased proliferation
• ovariectomized mice treated with E2 and P4 exhibit increased vascularization compared to in similarly treated Errfi1tm1Jwj homozygotes

Mouse Models of Human Disease
OMIM ID Ref(s)
Endometrial Cancer 608089 J:150007





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory