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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Lck-Jak3)1Ljb
transgene insertion 1, Leslie J Berg
MGI:3769344
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Jak3tm1Ljb/Jak3tm1Ljb
Tg(Lck-Jak3)1Ljb/0
involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10 MGI:3769355


Genotype
MGI:3769355
cx1
Allelic
Composition
Jak3tm1Ljb/Jak3tm1Ljb
Tg(Lck-Jak3)1Ljb/0
Genetic
Background
involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3tm1Ljb mutation (1 available); any Jak3 mutation (84 available)
Tg(Lck-Jak3)1Ljb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• unlike null mice without the transgene, thymic cellularity, the ratio of CD4+ to CD8+ cells in the thymus, T cell maturation in the spleen, and the numbers of gamma delta T and NK cells are normal
• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is reduced
• absence of CD45R+ IgM+ cells in the bone marrow

hematopoietic system
• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is reduced
• absence of CD45R+ IgM+ cells in the bone marrow

cellular
• the proliferative response of splenic T cells in response to T cell receptor plus CD28 stimulation is reduced





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory