All Phenotypes Fgf12<tm1Gol> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgf12^tm1Gol
targeted mutation 1, Mitchell Goldfarb
MGI:3768545

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf12^tm1Gol/Fgf12^tm1Gol	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3768546
cx2	Fgf12^tm1Gol/Fgf12^tm1Gol Fgf14^tm1Dor/Fgf14^tm1Dor	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:3768547

Allelic Composition	Fgf12^tm1Gol/Fgf12^tm1Gol
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf12^tm1Gol mutation (0 available); any Fgf12 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:128732 )

N	• mice perform normally in several motor tasks • cerebellar granule cells show normal intrinsic excitability

Allelic Composition	Fgf12^tm1Gol/Fgf12^tm1Gol Fgf14^tm1Dor/Fgf14^tm1Dor
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf12^tm1Gol mutation (0 available); any Fgf12 mutation (16 available)
Fgf14^tm1Dor mutation (0 available); any Fgf14 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal response to new environment ( J:128732 )

• mice exhibit increased activity when placed in a new environment

ataxia ( J:128732 )

• severe

decreased grip strength ( J:128732 )

• mice fall off a grid when titled at a 45 degree angle and do not pull a rod with any measurable force when pulled backwards by their tails

weakness ( J:128732 )

abnormal gait ( J:128732 )

hyperactivity ( J:128732 )

• mice exhibit increased activity when disturbed or placed in a new environment

nervous system

abnormal CNS synaptic transmission ( J:128732 )

• granule neuron excitability is more severely impaired than in Fgf14^tm1Dor mice (1 firing compared to 2 in Fgf14^tm1Dor mice)

abnormal channel response ( J:128732 )

• sodium channel inactivation parameters are altered in cerebellar granule neurons

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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