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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-MAPT*P301L)2Vln
transgene insertion 2, Fred Van Leuven
MGI:3768525
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln FVB/N-Tg(Thy1-MAPT*P301L)2Vln MGI:3771317


Genotype
MGI:3771317
tg1
Allelic
Composition
Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln
Genetic
Background
FVB/N-Tg(Thy1-MAPT*P301L)2Vln
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all homozygous mice died by 11-13 months of age
• direct cause of death could not determined

behavior/neurological
• less severe clasping of limbs in old (9-12 months) mice when lifted by the tail showing only partial retraction and still spreading toes
• most homozygous mice showed moderate to severe decline in ambulation in the home cage by age 9-10 months
• only some of oldest mice revealed a motor deficit on beam walk test
• paralysis progressed to include the forelimbs with age in all animal by age 9-10 months
• minor paresis of the hind limbs in some mice at 6 months
• no motor problems before age 6 months

growth/size/body
• due to muscle and tissue wasting by 9-10 months

nervous system
N
• axonal dilations were completely absent in brain and spinal cord at any age
• neurofibrillary pathology was evident in all old mice by silver impregnation and fluorescent staining with thioflavin S and X-34
• positive tauopathy was observed in brain and spinal cord neurons
• fraction of neuronal tau in aging mice was hyper phosphorylated concomitant with conformational changes and aggregation co-localizing in the same neurons

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:96869





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory