All Phenotypes Tg(Mnx1-GFP)1Slp MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Mnx1-GFP)1Slp
transgene insertion 1, Samuel L Pfaff
MGI:3767834

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fgfr1^tm1Upir/Fgfr1^tm1Upir Tg(Mnx1-GFP)1Slp/? Tg(Nes-cre)1Kln/?	Not Specified	MGI:3767836
cx2	Mycbp2^mgln/Mycbp2^mgln Tg(Mnx1-GFP)1Slp/0	involves: C3H * C57BL/6 * DBA/2J	MGI:3779029
cx3	Isl2^{tm3.1(Mnx1-Lhx3)Slp}/Isl2⁺ Tg(Mnx1-GFP)1Slp/?	Not Specified	MGI:3767837
cx4	Map3k12^tm1.1Lewc/Map3k12^tm1.1Lewc Tg(Mnx1-GFP)1Slp/0	Not Specified	MGI:5294553

Allelic Composition	Fgfr1^tm1Upir/Fgfr1^tm1Upir Tg(Mnx1-GFP)1Slp/? Tg(Nes-cre)1Kln/?
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1Upir mutation (0 available); any Fgfr1 mutation (221 available)
Tg(Mnx1-GFP)1Slp mutation (0 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:122940 )

• mice display motor axon guidance defects in the area where medial-class spinal motor neuron axons turn from the spinal nerve towards the dermomyotome

abnormal motor neuron morphology ( J:122940 )

• mice display motor axon guidance defects in the area where medial-class spinal motor neuron axons turn from the spinal nerve towards the dermomyotome

• motor neuron axons are less fasciculated than in heterozygotes

• unlike in wild-type mice, motor neuron axons growth far into the dorsal root ganglia

cellular

abnormal axon guidance ( J:122940 )

• mice display motor axon guidance defects in the area where medial-class spinal motor neuron axons turn from the spinal nerve towards the dermomyotome

Allelic Composition	Mycbp2^mgln/Mycbp2^mgln Tg(Mnx1-GFP)1Slp/0
Genetic Background	involves: C3H * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mycbp2^mgln mutation (0 available); any Mycbp2 mutation (223 available)
Tg(Mnx1-GFP)1Slp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron innervation pattern ( J:132726 )

• medial-class spinal motor neuron axons (MMCm) axons emerging from the spinal cord growth in the wrong direction over short distances unlike in wild-type mice

Allelic Composition	Isl2^{tm3.1(Mnx1-Lhx3)Slp}/Isl2⁺ Tg(Mnx1-GFP)1Slp/?
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl2^{tm3.1(Mnx1-Lhx3)Slp} mutation (0 available); any Isl2 mutation (28 available)
Tg(Mnx1-GFP)1Slp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron morphology ( J:122940 )

• the increased number of axons attracted to the dermomyotome is due to an increase in GFP+ neurons and not other neuronal types

Allelic Composition	Map3k12^tm1.1Lewc/Map3k12^tm1.1Lewc Tg(Mnx1-GFP)1Slp/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k12^tm1.1Lewc mutation (0 available); any Map3k12 mutation (39 available)
Tg(Mnx1-GFP)1Slp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:176956 )

N	• motor and sensory axon outgrowth is normal

increased motor neuron number ( J:176956 )

• doubled at E15.5 and E17.5

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