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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Tek-Jam3)1Maal
transgene insertion 1, Michel Aurrand-Lions
MGI:3767832
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Jam3tm1Rha/Jam3tm1Rha
Tg(Tek-Jam3)1Maal/0
B6.Cg-Jam3tm1Rha Tg(Tek-Jam3)1Maal MGI:5502441
cx2
Jam3tm1Rha/Jam3tm1Rha
Tg(Tek-Jam3)1Maal/?
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:3768529
tg3
Tg(Tek-Jam3)1Maal/? B6.Cg-Tg(Tek-Jam3)1Maal MGI:3768528


Genotype
MGI:5502441
cx1
Allelic
Composition
Jam3tm1Rha/Jam3tm1Rha
Tg(Tek-Jam3)1Maal/0
Genetic
Background
B6.Cg-Jam3tm1Rha Tg(Tek-Jam3)1Maal
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jam3tm1Rha mutation (0 available); any Jam3 mutation (24 available)
Tg(Tek-Jam3)1Maal mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• percentage of mutants that survive to weaning is reduced (8.2% vs. the expected 12.5%)

nervous system
• about 65% of mutants develop hydrocephalus




Genotype
MGI:3768529
cx2
Allelic
Composition
Jam3tm1Rha/Jam3tm1Rha
Tg(Tek-Jam3)1Maal/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jam3tm1Rha mutation (0 available); any Jam3 mutation (24 available)
Tg(Tek-Jam3)1Maal mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike Jam3tm1Rha homozygotes, mice do not exhibit any postnatal lethality due to housing conditions

reproductive system

digestive/alimentary system

immune system
N
• unlike Jam3tm1Rha homozygotes, leukocyte homeostasis is normal

growth/size/body




Genotype
MGI:3768528
tg3
Allelic
Composition
Tg(Tek-Jam3)1Maal/?
Genetic
Background
B6.Cg-Tg(Tek-Jam3)1Maal
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following injection of IL-1beta into the peritoneum to induce peritonitis, total leukocyte count is increased and there is a 3-fold increase in the percent of neutrophils that migrate into the peritoneal cavity compared to wild-type mice
• 30 minutes after stimulation with LPS leukocytes accumulate in the vessels and airways in the lungs unlike in wild-type mice
• following injection of IL-1beta into the peritoneum to induce peritonitis, the number of migrating neutrophils is increased 6-fold (2.44x106+/-1x106 compared to 0.382x106+/-0.124x106 in wild-type mice)
• following injection of IL-1beta, leukocyte transmigration is increased 2-fold compared to in wild-type mice
• following injection of IL-1beta, leukocyte adhesion is increased 2-fold compared to in wild-type mice
• following intranasal LPS challenge, the number of granulocytes is increased by 4-fol and the number of inflammatory monocytes is increased by 2-fold in bronchoalveolar lavage fluid

respiratory system
• following intranasal LPS challenge, the number of granulocytes is increased by 4-fol and the number of inflammatory monocytes is increased by 2-fold in bronchoalveolar lavage fluid

digestive/alimentary system
• following injection of IL-1beta into the peritoneum to induce peritonitis, total leukocyte count is increased and there is a 3-fold increase in the percent of neutrophils that migrate into the peritoneal cavity compared to wild-type mice

cellular
• following injection of IL-1beta into the peritoneum to induce peritonitis, the number of migrating neutrophils is increased 6-fold (2.44x106+/-1x106 compared to 0.382x106+/-0.124x106 in wild-type mice)
• following injection of IL-1beta, leukocyte transmigration is increased 2-fold compared to in wild-type mice
• following injection of IL-1beta, leukocyte adhesion is increased 2-fold compared to in wild-type mice

hematopoietic system
• 30 minutes after stimulation with LPS leukocytes accumulate in the vessels and airways in the lungs unlike in wild-type mice
• following injection of IL-1beta into the peritoneum to induce peritonitis, the number of migrating neutrophils is increased 6-fold (2.44x106+/-1x106 compared to 0.382x106+/-0.124x106 in wild-type mice)
• following injection of IL-1beta, leukocyte transmigration is increased 2-fold compared to in wild-type mice
• following injection of IL-1beta, leukocyte adhesion is increased 2-fold compared to in wild-type mice





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory