Phenotypes associated with this allele

• Allele Symbol: Cnpy3^tm1Kmiy
• Allele Name: targeted mutation 1, Kensuke Miyake
• Allele ID: MGI:3767622
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnpy3^tm1Kmiy/Cnpy3^tm1Kmiy	involves: C57BL/6	MGI:3767623

Genotype
MGI:3767623

hm1

• Allelic Composition: Cnpy3^tm1Kmiy/Cnpy3^tm1Kmiy
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:128513 )

• 10 of 17 mice die by the end of the weaning period

immune system

abnormal lymphocyte physiology ( J:128513 )

• lymphocytes exhibit decreased response to Toll-like receptor ligands

abnormal macrophage physiology ( J:128513 )

• macrophages exhibit decreased response to Toll-like receptor ligands

decreased interleukin-6 secretion ( J:128513 )

• bone marrow dendritic cells produce reduced amounts of IL-6 in response to Toll-like receptor ligands

decreased tumor necrosis factor secretion ( J:128513 )

• bone marrow dendritic cells produce reduced amounts of TNF-alpha in response to Toll-like receptor ligands

growth/size/body

decreased body size ( J:128513 )

• mice are of normal size at birth but become runted

postnatal growth retardation ( J:128513 )

hematopoietic system

abnormal lymphocyte physiology ( J:128513 )

• lymphocytes exhibit decreased response to Toll-like receptor ligands

abnormal macrophage physiology ( J:128513 )

• macrophages exhibit decreased response to Toll-like receptor ligands