Phenotypes associated with this allele

• Allele Symbol: Tenm3^tm1Cal
• Allele Name: targeted mutation 1, Catherine A Leamey
• Allele ID: MGI:3767554
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tenm3^tm1Cal/Tenm3^tm1Cal	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3767561

Genotype
MGI:3767561

hm1

• Allelic Composition: Tenm3^tm1Cal/Tenm3^tm1Cal
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:128389 )

• Background Sensitivity: survival of mice backcrossed 3 times to C57BL/6 is impaired compared to mice of earlier backcross generations

nervous system

nervous system phenotype ( J:128389 )

N • gross brain morphology and the size, cellular density and lamination of the retina, dorsal lateral geniculate nucleus and visual cortex are similar to wild-type controls

abnormal sensory neuron innervation pattern ( J:128389 )

• ipsilateral projections of the retinal ganglion cells target an elongated, comet-shaped area of the dorsal lateral geniculate nucleus (dLGN)

• the difference in target area is more marked in rostral sections where the patch is narrower and elongated along the dorsomedial to ventrolateral axis

• in caudal sections the target area is expanded so that it abuts the dorsomedial border of the dLGN

• some retinal ganglion cell ipsilateral axons appear to have multiple terminal foci

• however, segregation of ipsilateral and contralateral projections is maintained and no defect in crossing of axons in the optic chiasm is detected

behavior/neurological

abnormal sensory capabilities/reflexes/nociception ( J:128389 )

• mice show impaired performance in a visually mediated behavioral tasks (vertical placement, horizontal placement, and a modified version of the visual cliff test)

• however, somatosensory cue-mediated performance in the vertical placement assay is similar to wild-type controls

• following treatment with tetrodotoxin to induce monocular vision behavior of homozygous mice in the visual cliff test resembles that of wild-type mice exposed to tetrodotoxin