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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atoh1tm3Hzo
targeted mutation 3, Huda Y Zoghbi
MGI:3767172
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Atoh1tm3Hzo/Atoh1tm3Hzo involves: 129S7/SvEvBrd MGI:4420944
cn2
Atoh1tm3Hzo/Atoh1tm1Hzo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
involves: 129 * 129S7/SvEvBrd MGI:4420931
cn3
Atoh1tm3Hzo/Atoh1+
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
involves: 129 * 129S7/SvEvBrd * 129X1/SvJ MGI:4420943
cn4
Atoh1tm3Hzo/Atoh1tm1Hzo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
involves: 129 * 129S7/SvEvBrd * 129X1/SvJ MGI:4420935
cn5
Atoh1tm2Hzo/Atoh1tm3Hzo
Tg(Fabp1-cre)1Jig/0
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N * SJL MGI:3767181
cn6
Atoh1tm2Hzo/Atoh1tm3Hzo
Tg(Vil1-cre)997Gum/0
involves: 129S7/SvEvBrd * C57BL/6J * SJL MGI:3767180


Genotype
MGI:4420944
cn1
Allelic
Composition
Atoh1tm3Hzo/Atoh1tm3Hzo
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh1tm3Hzo mutation (1 available); any Atoh1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• after adenoviral cre infection, proliferation of granule neuron precursors in response to stimulation by sonic hedgehog for 3 days is decreased

cellular
• after adenoviral cre infection, proliferation of granule neuron precursors in response to stimulation by sonic hedgehog for 3 days is decreased




Genotype
MGI:4420931
cn2
Allelic
Composition
Atoh1tm3Hzo/Atoh1tm1Hzo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic
Background
involves: 129 * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh1tm1Hzo mutation (0 available); any Atoh1 mutation (22 available)
Atoh1tm3Hzo mutation (1 available); any Atoh1 mutation (22 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (745 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• after tamoxifen treatment, the external granule cell layer is much thinner than that of control littermates
• after tamoxifen treatment, the layer is depleted of cycling immature precursors




Genotype
MGI:4420943
cn3
Allelic
Composition
Atoh1tm3Hzo/Atoh1+
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic
Background
involves: 129 * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh1tm3Hzo mutation (1 available); any Atoh1 mutation (22 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (745 available)
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• ectopic masses show numerous mitotic granule neuron precursors 10 days after tamoxifen treatment
• 10 days after tamoxifen treatment, neoplastic and preneoplastic lesions in which the external granule layer lacks the normal layered structure develop in the external layer of the cerebellum
• hypertrophic 10 days after tamoxifen treatment
• 10 days after tamoxifen treatment, neoplastic and preneoplastic lesions in which the external granule layer lacks the normal layered structure develop in the external layer of the cerebellum

cellular
• ectopic masses show numerous mitotic granule neuron precursors 10 days after tamoxifen treatment




Genotype
MGI:4420935
cn4
Allelic
Composition
Atoh1tm3Hzo/Atoh1tm1Hzo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic
Background
involves: 129 * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh1tm1Hzo mutation (0 available); any Atoh1 mutation (22 available)
Atoh1tm3Hzo mutation (1 available); any Atoh1 mutation (22 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (745 available)
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• no cycling granule neuron precursor cells are detected in the external granule cell layer 10 days after tamoxifen treatment
• 10 days after tamoxifen treatment
• 10 days after tamoxifen treatment most mice have atrophic cerebella

cellular
• no cycling granule neuron precursor cells are detected in the external granule cell layer 10 days after tamoxifen treatment




Genotype
MGI:3767181
cn5
Allelic
Composition
Atoh1tm2Hzo/Atoh1tm3Hzo
Tg(Fabp1-cre)1Jig/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh1tm2Hzo mutation (1 available); any Atoh1 mutation (22 available)
Atoh1tm3Hzo mutation (1 available); any Atoh1 mutation (22 available)
Tg(Fabp1-cre)1Jig mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike mice with complete recombination of the floxed allele in the entire intestinal epithelium, mice with a mosaic pattern of recombination show no increase in mortality up to at least 1 year of age

digestive/alimentary system
• the small intestine contains patches of abnormal crypts with a recombined allele mixed with areas of normal crypts with an unrecombined allele
• crypts with the recombined allele completely lack goblet, Paneth, and enteroendocrine cells instead containing only absorptive enterocytes
• a significant increase in BrdU+ cells and mitotic figures is seen in crypts with a recombined allele
• crypts with a recombined allele are smaller than neighboring crypts in which recombination did not occur
• the adaptive response following resection of the middle 50% of the small bowel is blunted with a smaller increase in crypt depth compared to control mice

endocrine/exocrine glands
• the small intestine contains patches of abnormal crypts with a recombined allele mixed with areas of normal crypts with an unrecombined allele
• crypts with the recombined allele completely lack goblet, Paneth, and enteroendocrine cells instead containing only absorptive enterocytes
• a significant increase in BrdU+ cells and mitotic figures is seen in crypts with a recombined allele
• crypts with a recombined allele are smaller than neighboring crypts in which recombination did not occur




Genotype
MGI:3767180
cn6
Allelic
Composition
Atoh1tm2Hzo/Atoh1tm3Hzo
Tg(Vil1-cre)997Gum/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh1tm2Hzo mutation (1 available); any Atoh1 mutation (22 available)
Atoh1tm3Hzo mutation (1 available); any Atoh1 mutation (22 available)
Tg(Vil1-cre)997Gum mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mutants are found at P14





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory