Phenotypes associated with this allele

• Allele Symbol: Fbxl20^tm1Seto
• Allele Name: targeted mutation 1, Mitsutoshi Setou
• Allele ID: MGI:3765911
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxl20^tm1Seto/Fbxl20^tm1Seto	involves: 129P2/OlaHsd * C57BL/6J	MGI:3765914

Genotype
MGI:3765914

hm1

• Allelic Composition: Fbxl20^tm1Seto/Fbxl20^tm1Seto
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:127941 )

• mice exhibit a reduced lifespan compared to wild-type mice

lethality throughout fetal growth and development, incomplete penetrance ( J:127941 )

• fewer than expected mice are born (19% instead of the expected 25%)

nervous system

abnormal miniature excitatory postsynaptic currents ( J:127941 )

• miniature excitatory postsynaptic current frequency is increased (3.05+/-1.12 Hz compared to 0.91+/-0.23 Hz in wild-type mice)

• the effect of MG132 or epoxomicin on miniature excitatory postsynaptic current frequency is abolished

decreased paired-pulse facilitation ( J:127941 )

• paired pulse facilitation (PPF) is decreased at every stimulation interval

• the effect of MG132 on PPF ratio is reduced compared to in wild-type mice

endocrine/exocrine glands

small pancreas ( J:127941 )

growth/size/body

decreased body size ( J:127941 )