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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ncor2tm1Rsd
targeted mutation 1, Michael G Rosenfeld
MGI:3765904
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ncor2tm1Rsd/Ncor2tm1Rsd involves: 129S1/Sv * 129X1/SvJ MGI:3765908
cx2
Ncor1tm1Rsd/Ncor1+
Ncor2tm1Rsd/Ncor2+
involves: 129/Sv * 129S1/Sv * 129X1/SvJ MGI:3765909
cx3
Foxp1Gt(S17-4A1)Sor/Foxp1+
Ncor2tm1Rsd/Ncor2+
involves: 129/Sv * 129S4/SvJaeSor MGI:3783622
cx4
Ncor2tm1Rsd/Ncor2tm1Rsd
Tg(Myh6-Ncor2)1Kjep/?
involves: 129/Sv * BALB/c * C57BL/6 MGI:3765964


Genotype
MGI:3765908
hm1
Allelic
Composition
Ncor2tm1Rsd/Ncor2tm1Rsd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncor2tm1Rsd mutation (1 available); any Ncor2 mutation (141 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die before E16.5 due to heart defects

cardiovascular system
• mice die before E16.5 due to heart defects
• at E11.5 and E14.5
• at E11.5 and E14.5

nervous system
• after 4 to 6 days in culture, cortical progenitor cells exhibit decreased proliferation with signs of differentiation unlike to wild-type cells
• E13 cortical progenitor cells are multipotent
• at E14.5, the hippocampus, neocortex and palaeocortex are slightly smaller than in wild-type mice

cellular
• after 4 to 6 days in culture, cortical progenitor cells exhibit decreased proliferation with signs of differentiation unlike to wild-type cells
• E13 cortical progenitor cells are multipotent




Genotype
MGI:3765909
cx2
Allelic
Composition
Ncor1tm1Rsd/Ncor1+
Ncor2tm1Rsd/Ncor2+
Genetic
Background
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncor1tm1Rsd mutation (1 available); any Ncor1 mutation (364 available)
Ncor2tm1Rsd mutation (1 available); any Ncor2 mutation (141 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• unlike in mice homozygous for either gene, cortical progenitor cells spontaneously differentiate into astroglia-like cells

cellular
• unlike in mice homozygous for either gene, cortical progenitor cells spontaneously differentiate into astroglia-like cells




Genotype
MGI:3783622
cx3
Allelic
Composition
Foxp1Gt(S17-4A1)Sor/Foxp1+
Ncor2tm1Rsd/Ncor2+
Genetic
Background
involves: 129/Sv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1Gt(S17-4A1)Sor mutation (0 available); any Foxp1 mutation (56 available)
Ncor2tm1Rsd mutation (1 available); any Ncor2 mutation (141 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• in 50% of mice at E14.5

mortality/aging
• fewer than expected mice are recovered at birth

cardiovascular system
• in 50% of mice at E14.5
• in 50% of mice at E14.5




Genotype
MGI:3765964
cx4
Allelic
Composition
Ncor2tm1Rsd/Ncor2tm1Rsd
Tg(Myh6-Ncor2)1Kjep/?
Genetic
Background
involves: 129/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncor2tm1Rsd mutation (1 available); any Ncor2 mutation (141 available)
Tg(Myh6-Ncor2)1Kjep mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice survive until birth with no heart defects

nervous system
• at E17.5, mice exhibit a shift in the proportional volume of the dorsal and ventral telencephalon
• the neocortical plate is thinned in the medial and lateral regions extending throughout the rostro-caudal axis of the brain and includes the hippocampus
• the ventral-lateral boundaries of the neocortex and palaeocortex terminate in more dorsa positions
• axonal projections linking opposing cortical hemispheres are altered compared to in wild-type mice
• axons between the thalamus and cortex are more highly represented than in wild-type mice

craniofacial
• at E17.5 mice exhibit secondary cleft palate
• at E17.5, palatal shelves do not meet at the midline (Sup. Fig. 1e)

digestive/alimentary system
• at E17.5 mice exhibit secondary cleft palate
• at E17.5, palatal shelves do not meet at the midline (Sup. Fig. 1e)

growth/size/body
• at E17.5 mice exhibit secondary cleft palate
• at E17.5, palatal shelves do not meet at the midline (Sup. Fig. 1e)





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory