Analysis Tools
nervous system
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• at 12 months, mice exhibit a 3- to 4-fold increase in Tau lesions compared with Tg(Thy1-MAPT*P301S)2541Godt mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 months, mice exhibit a 3- to 4-fold increase in Tau lesions compared with Tg(Thy1-MAPT*P301S)2541Godt mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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• mice exhibit an accumulation of Dan-amyloid in separate plaques from amyloid beta plaques
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• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increase in microgliosis
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• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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• increase in microgliosis
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• increase in microgliosis
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• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:178230 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants exhibit a similar amount of cortical amyloid beta-positive plaques as seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr transgenic mice
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• mutants exhibit a similar amount of cortical amyloid beta-positive plaques as seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr transgenic mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced quantity of Abeta fragments
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• reduced quantity of Abeta fragments
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show a similar amyloid beta plaque load as single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes
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• mice show a similar amyloid beta plaque load as single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes
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| N |
• mice show rescue of the mild hyperactivity seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes
• mice show complete rescue of the impaired freezing behavior seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes, restoring associative memory
• mice show improved spatial memory function compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no clear difference in Abeta cleavage product amounts from APP relative to controls as determined by Western blot
• clearly less Abeta as determined by ELISA
• 76% reduction in area covered by plaques
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• no clear difference in Abeta cleavage product amounts from APP relative to controls as determined by Western blot
• clearly less Abeta as determined by ELISA
• 76% reduction in area covered by plaques
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show a reduction in the number of plaque-associated myeloid cells compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating an impairment in myeloid cell accumulation around plaques
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• proliferation of myeloid cells is reduced compared to levels in single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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• mice show a 31% and 36% reduction in compact fibrillary, thioflavin S positive plaque number and percent area, respectively, in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating altered plaque structure
• however, the total number of cortical plaques and percent area is similar to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show a decrease in soluble amyloid beta 1-40 in the cortex and thus an increased ratio of amyloid beta 42/40 compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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• mice show a 31% and 36% reduction in compact fibrillary, thioflavin S positive plaque number and percent area, respectively, in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating altered plaque structure
• however, the total number of cortical plaques and percent area is similar to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show a decrease in soluble amyloid beta 1-40 in the cortex and thus an increased ratio of amyloid beta 42/40 compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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• marker analysis indicates increased plaque-associated neuritic dystrophy compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show a reduction in the number of plaque-associated myeloid cells compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating an impairment in myeloid cell accumulation around plaques
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• proliferation of myeloid cells is reduced compared to levels in single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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• mice exhibit a modest increase in the total cortical plaque number and percent area compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show an increase in soluble amyloid beta 1-40 in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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• mice exhibit a modest increase in the total cortical plaque number and percent area compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show an increase in soluble amyloid beta 1-40 in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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• marker analysis indicates increased plaque-associated neuritic dystrophy compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants develop amyloid plaques over time that increase in size, with the highest rate of new plaque appearance in mice between 4 and 5 months of age
• newly formed plaques and preexisting plaques grow at similar rates
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• mutants develop amyloid plaques over time that increase in size, with the highest rate of new plaque appearance in mice between 4 and 5 months of age
• newly formed plaques and preexisting plaques grow at similar rates
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:180835 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show impaired associative memory
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• mice show impaired preference for the target quadrant in the probe test of the Morris Water Maze indicating impaired spatial memory function
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• mild hyperactivity
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• mice show an increase in the immunoreactivity to Tom20, a marker for mitochondrial localization, in the soma, indicating accumulation of mitochondria at the somata of nerve cells and impaired mitochondrial trafficking
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• amyloid beta plaque
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• amyloid beta plaque
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:234763 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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