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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
transgene insertion 21, Mathias Jucker
MGI:3765351
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0
B6.Cg-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr Tg(Thy1-MAPT*P301S)2541Godt MGI:4452492
cx2
Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
C57BL/6-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:4452489
cx3
Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:5301408
cx4
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
FVB.Cg-Abcc1tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:5301407
cx5
Abcg2tm1Ahs/Abcg2tm1Ahs
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
FVB.Cg-Abcg2tm1Ahs Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:5301409
cx6
Flot1tm1.1Arte/Flot1tm1.1Arte
Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5697919
cx7
Flot1tm1.1Arte/Flot1tm1.1Arte
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
involves: C57BL/6J MGI:5697918
tg8
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0 C57BL/6-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:5313530


Genotype
MGI:4452492
cx1
Allelic
Composition
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0
Genetic
Background
B6.Cg-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr Tg(Thy1-MAPT*P301S)2541Godt
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 12 months, mice exhibit a 3- to 4-fold increase in Tau lesions compared with Tg(Thy1-MAPT*P301S)2541Godt mice




Genotype
MGI:4452489
cx2
Allelic
Composition
Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background
C57BL/6-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism
• mice exhibit an accumulation of Dan-amyloid in separate plaques from amyloid beta plaques
• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice




Genotype
MGI:5301408
cx3
Allelic
Composition
Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background
FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1atm1Bor mutation (3 available); any Abcb1a mutation (34 available)
Abcb1btm1Bor mutation (2 available); any Abcb1b mutation (36 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism
• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice




Genotype
MGI:5301407
cx4
Allelic
Composition
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background
FVB.Cg-Abcc1tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc1tm1Bor mutation (0 available); any Abcc1 mutation (34 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increase in microgliosis
• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

hematopoietic system
• increase in microgliosis

immune system
• increase in microgliosis

homeostasis/metabolism
• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:178230




Genotype
MGI:5301409
cx5
Allelic
Composition
Abcg2tm1Ahs/Abcg2tm1Ahs
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background
FVB.Cg-Abcg2tm1Ahs Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg2tm1Ahs mutation (2 available); any Abcg2 mutation (52 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exhibit a similar amount of cortical amyloid beta-positive plaques as seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr transgenic mice

homeostasis/metabolism
• mutants exhibit a similar amount of cortical amyloid beta-positive plaques as seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr transgenic mice




Genotype
MGI:5697919
cx6
Allelic
Composition
Flot1tm1.1Arte/Flot1tm1.1Arte
Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot1tm1.1Arte mutation (0 available); any Flot1 mutation (5 available)
Flot2Gt(258D8)Cmhd mutation (0 available); any Flot2 mutation (13 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• reduced quantity of Abeta fragments

nervous system
• reduced quantity of Abeta fragments




Genotype
MGI:5697918
cx7
Allelic
Composition
Flot1tm1.1Arte/Flot1tm1.1Arte
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot1tm1.1Arte mutation (0 available); any Flot1 mutation (5 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• no clear difference in Abeta cleavage product amounts from APP relative to controls as determined by Western blot
• clearly less Abeta as determined by ELISA
• 76% reduction in area covered by plaques

nervous system
• no clear difference in Abeta cleavage product amounts from APP relative to controls as determined by Western blot
• clearly less Abeta as determined by ELISA
• 76% reduction in area covered by plaques




Genotype
MGI:5313530
tg8
Allelic
Composition
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background
C57BL/6-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants develop amyloid plaques over time that increase in size, with the highest rate of new plaque appearance in mice between 4 and 5 months of age
• newly formed plaques and preexisting plaques grow at similar rates

homeostasis/metabolism
• mutants develop amyloid plaques over time that increase in size, with the highest rate of new plaque appearance in mice between 4 and 5 months of age
• newly formed plaques and preexisting plaques grow at similar rates

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:180835





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory