• at 12 months, mice exhibit a 3- to 4-fold increase in Tau lesions compared with Tg(Thy1-MAPT*P301S)2541Godt mice

• mice exhibit an accumulation of Dan-amyloid in separate plaques from amyloid beta plaques

• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

• increase in microgliosis

• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

• increase in microgliosis

• increase in microgliosis

• mutants exhibit a similar amount of cortical amyloid beta-positive plaques as seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr transgenic mice

• mutants exhibit a similar amount of cortical amyloid beta-positive plaques as seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr transgenic mice

• mutants develop amyloid plaques over time that increase in size, with the highest rate of new plaque appearance in mice between 4 and 5 months of age

• newly formed plaques and preexisting plaques grow at similar rates

• mutants develop amyloid plaques over time that increase in size, with the highest rate of new plaque appearance in mice between 4 and 5 months of age

• newly formed plaques and preexisting plaques grow at similar rates